Micropatterning Polydiacetylene Supramolecular Vesicles on Glass Substrates using a Pre-Patterned Hydrophobic Thin Film

Abstract

A micropatterning method for depositing polydiacetylene (PDA) supramolecular vesicles on glass substrates, employing a pre-patterned hydrophobic thin film, is presented. The pre-patterned hydrophobic thin film is used to define surface-exposed regions on hydrophilic glass substrates where selective immobilization of PDA vesicles takes place. The observation that fluorescent patterns are generated by heat treatment of the deposited PDAs demonstrates that the vesicles are successfully immobilized in the form of micropatterns. Finally, the possibility that this strategy may be used to design a vesicle-based sensor chip system is demonstrated by the observation that fluorescence patterns are generated when the immobilized PDA vesicles interact with cyclodextrin.