Autophagy and antiviral immunity

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Autophagy is an ancient pathway designed to maintain cellular homeostasis by degrading long-lived proteins and organelles in the cytosol. Recent studies demonstrate that autophagy is utilized by the cells of the innate and adaptive immune systems to combat viral infections. Autophagy plays a key role in recognizing signatures of viral infection, and represents a critical effector mechanism to restrict viral replication. On the other hand, autophagosomes have been exploited by certain viruses as a niche for viral replication. Furthermore, autophagy can be used to deliver endogenous viral antigens to the MHC class 11 loading compartment, allowing activation of CD4 T cells. In this review, we describe recent advances in the field of autophagy as it relates to innate and adaptive antiviral immune responses.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2008-02
Language
English
Article Type
Review
Keywords

TRANSLATION INITIATION-FACTOR; SIMPLEX-VIRUS TYPE-1; CLASS-II MOLECULES; RIG-I; CELLULAR AUTOPHAGY; INNATE IMMUNITY; PROTEIN-KINASE; CORONAVIRUS REPLICATION; ENDOPLASMIC-RETICULUM; VIRAL RECOGNITION

Citation

CURRENT OPINION IN IMMUNOLOGY, v.20, no.1, pp.23 - 29

ISSN
0952-7915
DOI
10.1016/j.coi.2008.01.001
URI
http://hdl.handle.net/10203/92958
Appears in Collection
MSE-Journal Papers(저널논문)
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