PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

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Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid-containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-kappa B through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif-like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2006-07
Language
English
Article Type
Article
Keywords

PATTERN-RECOGNITION RECEPTOR; IMD-PATHWAY; BORDETELLA-PERTUSSIS; TRACHEAL CYTOTOXIN; IN-VITRO; PROTEIN; ACTIVATION; COMPLEX; IDENTIFICATION; MELANOGASTER

Citation

NATURE IMMUNOLOGY, v.7, no.7, pp.715 - 723

ISSN
1529-2908
DOI
10.1038/ni1356
URI
http://hdl.handle.net/10203/92864
Appears in Collection
BS-Journal Papers(저널논문)
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