DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kaneko, Takashi | ko |
dc.contributor.author | Yano, Tamaki | ko |
dc.contributor.author | Aggarwal, Kamna | ko |
dc.contributor.author | Lim, Jae-Hong | ko |
dc.contributor.author | Ueda, Kazunori | ko |
dc.contributor.author | Oshima, Yoshiteru | ko |
dc.contributor.author | Peach, Camilla | ko |
dc.contributor.author | Erturk-Hasdemir, Deniz | ko |
dc.contributor.author | Goldman, William E. | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Kurata, Shoichiro | ko |
dc.contributor.author | Silverman, Neal | ko |
dc.date.accessioned | 2013-03-08T10:50:37Z | - |
dc.date.available | 2013-03-08T10:50:37Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | NATURE IMMUNOLOGY, v.7, no.7, pp.715 - 723 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92864 | - |
dc.description.abstract | Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid-containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-kappa B through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif-like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PATTERN-RECOGNITION RECEPTOR | - |
dc.subject | IMD-PATHWAY | - |
dc.subject | BORDETELLA-PERTUSSIS | - |
dc.subject | TRACHEAL CYTOTOXIN | - |
dc.subject | IN-VITRO | - |
dc.subject | PROTEIN | - |
dc.subject | ACTIVATION | - |
dc.subject | COMPLEX | - |
dc.subject | IDENTIFICATION | - |
dc.subject | MELANOGASTER | - |
dc.title | PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan | - |
dc.type | Article | - |
dc.identifier.wosid | 000238377700016 | - |
dc.identifier.scopusid | 2-s2.0-33745225236 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 715 | - |
dc.citation.endingpage | 723 | - |
dc.citation.publicationname | NATURE IMMUNOLOGY | - |
dc.identifier.doi | 10.1038/ni1356 | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Kaneko, Takashi | - |
dc.contributor.nonIdAuthor | Yano, Tamaki | - |
dc.contributor.nonIdAuthor | Aggarwal, Kamna | - |
dc.contributor.nonIdAuthor | Lim, Jae-Hong | - |
dc.contributor.nonIdAuthor | Ueda, Kazunori | - |
dc.contributor.nonIdAuthor | Oshima, Yoshiteru | - |
dc.contributor.nonIdAuthor | Peach, Camilla | - |
dc.contributor.nonIdAuthor | Erturk-Hasdemir, Deniz | - |
dc.contributor.nonIdAuthor | Goldman, William E. | - |
dc.contributor.nonIdAuthor | Kurata, Shoichiro | - |
dc.contributor.nonIdAuthor | Silverman, Neal | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION RECEPTOR | - |
dc.subject.keywordPlus | IMD-PATHWAY | - |
dc.subject.keywordPlus | BORDETELLA-PERTUSSIS | - |
dc.subject.keywordPlus | TRACHEAL CYTOTOXIN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MELANOGASTER | - |
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