In situ micro-sized gel-forming injectable implant using biodegradable amphiphilic graft copolymer

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A synthesized graft polymer is used as a biodegradable polymer for an in situ gel-forming injectable implant system. The amphiphilic character of the polymer in the graft structure lowered the viscosity of the polymer solution, which enabled easy injection. A micro-sized gel can be obtained with this system, which has not been found for previous in situ gel-forming systems with poly[(D,L-lactide)-co-glycolide] copolymer. In addition, a protein particle embedded gel exhibits good in vitro drug release performance as a result of the enhanced stability and shorter diffusion length.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2007-06
Language
English
Article Type
Article
Keywords

DRUG-DELIVERY; BLOCK-COPOLYMERS; RELEASE; MICROPARTICLES; ACID); SYSTEMS; MICROSPHERES; POLYMERS; VIVO

Citation

MACROMOLECULAR BIOSCIENCE, v.7, no.6, pp.784 - 788

ISSN
1616-5187
DOI
10.1002/mabi.200700045
URI
http://hdl.handle.net/10203/86575
Appears in Collection
CBE-Journal Papers(저널논문)
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