Protective Effects of epigallocatechin-3-gallate on ultraviolet light-induced skin damage. Skin pharmacology and Applied Skin physiology.

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It has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 +/- 144 and 286 +/- 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 +/- 45 and 191 +/- 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-kappaB and AP-1 binding activities were also inhibited by EGCG treatment. Copyright (C) 2001 S. Karger AG, Basel.
Publisher
S. Karger AG
Issue Date
2001
Language
ENG
Article Type
Article
Keywords

NF-KAPPA-B; HUMAN DERMAL FIBROBLASTS; GREEN TEA; INTERSTITIAL COLLAGENASE; TOPICAL APPLICATION; HYDROGEN-PEROXIDE; SINGLET OXYGEN; MURINE SKIN; ULTRAVIOLET; AP-1

Citation

SKIN PHARMACOLOGY AND PHYSIOLOGY, v.14, no.1, pp.11 - 19

ISSN
1422-2868
URI
http://hdl.handle.net/10203/79981
Appears in Collection
BS-Journal Papers(저널논문)
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