DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim J | - |
dc.contributor.author | Hwang JS | - |
dc.contributor.author | Cho YK | - |
dc.contributor.author | Han YK | - |
dc.contributor.author | Jeon YJ | - |
dc.contributor.author | Yang, Kyu Hwan | - |
dc.date.accessioned | 2013-03-03T18:52:17Z | - |
dc.date.available | 2013-03-03T18:52:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | SKIN PHARMACOLOGY AND PHYSIOLOGY, v.14, no.1, pp.11 - 19 | - |
dc.identifier.issn | 1422-2868 | - |
dc.identifier.uri | http://hdl.handle.net/10203/79981 | - |
dc.description.abstract | It has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 +/- 144 and 286 +/- 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 +/- 45 and 191 +/- 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-kappaB and AP-1 binding activities were also inhibited by EGCG treatment. Copyright (C) 2001 S. Karger AG, Basel. | - |
dc.language | ENG | - |
dc.publisher | S. Karger AG | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | HUMAN DERMAL FIBROBLASTS | - |
dc.subject | GREEN TEA | - |
dc.subject | INTERSTITIAL COLLAGENASE | - |
dc.subject | TOPICAL APPLICATION | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | SINGLET OXYGEN | - |
dc.subject | MURINE SKIN | - |
dc.subject | ULTRAVIOLET | - |
dc.subject | AP-1 | - |
dc.title | Protective Effects of epigallocatechin-3-gallate on ultraviolet light-induced skin damage. Skin pharmacology and Applied Skin physiology. | - |
dc.type | Article | - |
dc.identifier.wosid | 000166960900002 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 11 | - |
dc.citation.endingpage | 19 | - |
dc.citation.publicationname | SKIN PHARMACOLOGY AND PHYSIOLOGY | - |
dc.contributor.localauthor | Yang, Kyu Hwan | - |
dc.contributor.nonIdAuthor | Kim J | - |
dc.contributor.nonIdAuthor | Hwang JS | - |
dc.contributor.nonIdAuthor | Cho YK | - |
dc.contributor.nonIdAuthor | Han YK | - |
dc.contributor.nonIdAuthor | Jeon YJ | - |
dc.type.journalArticle | Article | - |
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