Protective Effects of epigallocatechin-3-gallate on ultraviolet light-induced skin damage. Skin pharmacology and Applied Skin physiology.

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dc.contributor.authorKim J-
dc.contributor.authorHwang JS-
dc.contributor.authorCho YK-
dc.contributor.authorHan YK-
dc.contributor.authorJeon YJ-
dc.contributor.authorYang, Kyu Hwan-
dc.date.accessioned2013-03-03T18:52:17Z-
dc.date.available2013-03-03T18:52:17Z-
dc.date.created2012-02-06-
dc.date.issued2001-
dc.identifier.citationSKIN PHARMACOLOGY AND PHYSIOLOGY, v.14, no.1, pp.11 - 19-
dc.identifier.issn1422-2868-
dc.identifier.urihttp://hdl.handle.net/10203/79981-
dc.description.abstractIt has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 +/- 144 and 286 +/- 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 +/- 45 and 191 +/- 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-kappaB and AP-1 binding activities were also inhibited by EGCG treatment. Copyright (C) 2001 S. Karger AG, Basel.-
dc.languageENG-
dc.publisherS. Karger AG-
dc.subjectNF-KAPPA-B-
dc.subjectHUMAN DERMAL FIBROBLASTS-
dc.subjectGREEN TEA-
dc.subjectINTERSTITIAL COLLAGENASE-
dc.subjectTOPICAL APPLICATION-
dc.subjectHYDROGEN-PEROXIDE-
dc.subjectSINGLET OXYGEN-
dc.subjectMURINE SKIN-
dc.subjectULTRAVIOLET-
dc.subjectAP-1-
dc.titleProtective Effects of epigallocatechin-3-gallate on ultraviolet light-induced skin damage. Skin pharmacology and Applied Skin physiology.-
dc.typeArticle-
dc.identifier.wosid000166960900002-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue1-
dc.citation.beginningpage11-
dc.citation.endingpage19-
dc.citation.publicationnameSKIN PHARMACOLOGY AND PHYSIOLOGY-
dc.contributor.localauthorYang, Kyu Hwan-
dc.contributor.nonIdAuthorKim J-
dc.contributor.nonIdAuthorHwang JS-
dc.contributor.nonIdAuthorCho YK-
dc.contributor.nonIdAuthorHan YK-
dc.contributor.nonIdAuthorJeon YJ-
dc.type.journalArticleArticle-
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