Expression of Fas-related genes in human hepatocellular carcinomas

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Hepatocellular carcinoma (HCC) is one of the tumors known to be resistant to Fas-mediated apoptosis. To elucidate the possible mechanisms of this resistance, we examined the mRNA transcripts of genes related to Fas in 10 hepatitis B virus (HBV)-associated HCC cell lines and six HBV-associated HCC tissues. Most of the HBV-associated HCC cell lines showed markedly decreased Fas expression. Some cell lines expressed FAP, a possible inhibitor of apoptosis, or showed downregulated expression of FADD or FLICE, molecules essential to Fas-mediated apoptosis. All six HBV-associated HCC tissues also showed decreased Fas expression compared with their non-malignant counterparts. Our data demonstrate that HBV-associated HCC showed a common defect in the expression of Fas, upregulation of FAP and downregulation of downstream molecules such as FADD and FLICE. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Publisher
ELSEVIER SCI IRELAND LTD
Issue Date
1998-12
Language
English
Article Type
Article
Keywords

CELL-SURFACE ANTIGEN; MEDIATED APOPTOSIS; SIGNALING COMPLEX; HEPATOMA-CELLS; DEATH DOMAIN; RECEPTOR; PROTEIN; CD95; LIGAND; LINES

Citation

CANCER LETTERS, v.134, no.2, pp.155 - 162

ISSN
0304-3835
DOI
10.1016/S0304-3835(98)00251-1
URI
http://hdl.handle.net/10203/77781
Appears in Collection
MSE-Journal Papers(저널논문)
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