DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Shin, JS | ko |
dc.contributor.author | Park, JH | ko |
dc.contributor.author | Kim, JJ | ko |
dc.contributor.author | Kim, H | ko |
dc.contributor.author | Kim, SJ | ko |
dc.date.accessioned | 2013-03-03T07:31:14Z | - |
dc.date.available | 2013-03-03T07:31:14Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1998-12 | - |
dc.identifier.citation | CANCER LETTERS, v.134, no.2, pp.155 - 162 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10203/77781 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the tumors known to be resistant to Fas-mediated apoptosis. To elucidate the possible mechanisms of this resistance, we examined the mRNA transcripts of genes related to Fas in 10 hepatitis B virus (HBV)-associated HCC cell lines and six HBV-associated HCC tissues. Most of the HBV-associated HCC cell lines showed markedly decreased Fas expression. Some cell lines expressed FAP, a possible inhibitor of apoptosis, or showed downregulated expression of FADD or FLICE, molecules essential to Fas-mediated apoptosis. All six HBV-associated HCC tissues also showed decreased Fas expression compared with their non-malignant counterparts. Our data demonstrate that HBV-associated HCC showed a common defect in the expression of Fas, upregulation of FAP and downregulation of downstream molecules such as FADD and FLICE. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI IRELAND LTD | - |
dc.subject | CELL-SURFACE ANTIGEN | - |
dc.subject | MEDIATED APOPTOSIS | - |
dc.subject | SIGNALING COMPLEX | - |
dc.subject | HEPATOMA-CELLS | - |
dc.subject | DEATH DOMAIN | - |
dc.subject | RECEPTOR | - |
dc.subject | PROTEIN | - |
dc.subject | CD95 | - |
dc.subject | LIGAND | - |
dc.subject | LINES | - |
dc.title | Expression of Fas-related genes in human hepatocellular carcinomas | - |
dc.type | Article | - |
dc.identifier.wosid | 000077949600005 | - |
dc.identifier.scopusid | 2-s2.0-0032434756 | - |
dc.type.rims | ART | - |
dc.citation.volume | 134 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 155 | - |
dc.citation.endingpage | 162 | - |
dc.citation.publicationname | CANCER LETTERS | - |
dc.identifier.doi | 10.1016/S0304-3835(98)00251-1 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Shin, JS | - |
dc.contributor.nonIdAuthor | Park, JH | - |
dc.contributor.nonIdAuthor | Kim, JJ | - |
dc.contributor.nonIdAuthor | Kim, H | - |
dc.contributor.nonIdAuthor | Kim, SJ | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Fas | - |
dc.subject.keywordAuthor | Fas-related genes | - |
dc.subject.keywordAuthor | Fas-mediated apoptosis | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordPlus | CELL-SURFACE ANTIGEN | - |
dc.subject.keywordPlus | MEDIATED APOPTOSIS | - |
dc.subject.keywordPlus | SIGNALING COMPLEX | - |
dc.subject.keywordPlus | HEPATOMA-CELLS | - |
dc.subject.keywordPlus | DEATH DOMAIN | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CD95 | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | LINES | - |
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