Herein, an organic light-emitting diode (OLED) is fabricated with increased luminous efficiency and biocompatibility by topographic DNA film. In addition to the natural abundance and biocompatibility of DNA, its semi-flexible characteristics facilitated the emergence of the liquid crystal phase, allowing the formation of a periodic wavy undulation structure by applying shear force. The resultant zigzag structure possesses sufficient periodicity and roughness, enhancing the effective scattering of emitted light. Furthermore, the DNA-coated red OLED demonstrates cell proliferative effects and exhibits high electrical and thermal stability even in a bent state, suggesting its potential application in attachable OLED-based light therapy.