Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats - Implications for obesity treatment

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Intense hyperleptinemia completely depletes adipocyte fat of normal rats within 14 days. To determine the mechanism, epididymal fat pads from normal wild-type (+/+) and obese (fa/fa) Zucker Diabetic Fatty (ZDF) donor rats were transplanted into normal +/+ and fa/fa ZDF recipients. Hyperleptinemia induced by adenovirus-leptin administration depleted all fat from native fat pads and from fat transplants from +/+ donors but not from transplants from ZDF(fa/fa) donors with defective leptin receptors. In both native and transplanted +/+ fat pads, large numbers of mitochondria were apparent, and genes involved in fatty acid oxidation were up-regulated. However, +/+ fat pads transplanted into fa/fa recipients did not respond to hyperleptinemia, suggesting lack of an essential leptin-stimulated cohormone(s). In +/+ but not in fa/fa rats, plasma catecholamine levels rose, and both P-STAT3 and P-CREB increased in adipose tissue, suggesting that both direct and indirect ( hypothalamic) leptin receptor-mediated actions of hyperleptinemia are involved in depletion of adipocyte fat.
Publisher
ELSEVIER
Issue Date
2006-12
Language
English
Article Type
Article
Citation

JOURNAL OF BIOLOGICAL CHEMISTRY, v.281, no.52, pp.40283 - 40291

DOI
10.1074/jbc.M607545200
URI
http://hdl.handle.net/10203/318872
Appears in Collection
MSE-Journal Papers(저널논문)
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