DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Wang, May-Yun | ko |
dc.contributor.author | Lee, Young | ko |
dc.contributor.author | Yu, Xinxin | ko |
dc.contributor.author | Ravazzola, Mariella | ko |
dc.contributor.author | Orci, Lelio | ko |
dc.contributor.author | Unger, Roger H. | ko |
dc.date.accessioned | 2024-03-26T08:00:09Z | - |
dc.date.available | 2024-03-26T08:00:09Z | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.created | 2024-03-26 | - |
dc.date.issued | 2006-12 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.281, no.52, pp.40283 - 40291 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318872 | - |
dc.description.abstract | Intense hyperleptinemia completely depletes adipocyte fat of normal rats within 14 days. To determine the mechanism, epididymal fat pads from normal wild-type (+/+) and obese (fa/fa) Zucker Diabetic Fatty (ZDF) donor rats were transplanted into normal +/+ and fa/fa ZDF recipients. Hyperleptinemia induced by adenovirus-leptin administration depleted all fat from native fat pads and from fat transplants from +/+ donors but not from transplants from ZDF(fa/fa) donors with defective leptin receptors. In both native and transplanted +/+ fat pads, large numbers of mitochondria were apparent, and genes involved in fatty acid oxidation were up-regulated. However, +/+ fat pads transplanted into fa/fa recipients did not respond to hyperleptinemia, suggesting lack of an essential leptin-stimulated cohormone(s). In +/+ but not in fa/fa rats, plasma catecholamine levels rose, and both P-STAT3 and P-CREB increased in adipose tissue, suggesting that both direct and indirect ( hypothalamic) leptin receptor-mediated actions of hyperleptinemia are involved in depletion of adipocyte fat. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.title | Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats - Implications for obesity treatment | - |
dc.type | Article | - |
dc.identifier.wosid | 000243033900059 | - |
dc.identifier.scopusid | 2-s2.0-33845979159 | - |
dc.type.rims | ART | - |
dc.citation.volume | 281 | - |
dc.citation.issue | 52 | - |
dc.citation.beginningpage | 40283 | - |
dc.citation.endingpage | 40291 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.identifier.doi | 10.1074/jbc.M607545200 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Wang, May-Yun | - |
dc.contributor.nonIdAuthor | Lee, Young | - |
dc.contributor.nonIdAuthor | Yu, Xinxin | - |
dc.contributor.nonIdAuthor | Ravazzola, Mariella | - |
dc.contributor.nonIdAuthor | Orci, Lelio | - |
dc.contributor.nonIdAuthor | Unger, Roger H. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | AMPHETAMINE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | COCAINE | - |
dc.subject.keywordPlus | WEIGHT | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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