Effects of n-3 PUFA on the CD4+ type 2 helper T-cell-mediated immune responses in Fat-1 mice

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Scope: It has been suggested that n-3 PUFA can be used as a preventive or therapeutic strategy to control allergic asthma. But little is known about the exact mechanisms by which n-3 PUFA modulates it. Here, the effects of elevated n-3 PUFA on ovalbumin (OVA) induced airway inflammation were investigated using Fat-1 transgenic mice that can convert n-6 PUFA to n-3 PUFA endogenously. Methods and results: First, we tested whether Fat-1 expression modulates CD4+ T-cell activation, proliferation, and differentiation in vitro and found that the Fat-1 expression attenuated all of these CD4(+) T-cell responses by suppression of T-cell receptor mediated signaling and cytokine-mediated phosphorylation of STATs. When the Fat-1 mice were sensitized and challenged with the OVA, they showed a significant decrease in the recruitment of inflammatory cells into airway, the production of Th2 cytokines, eotaxin, and mucin in the lung, and the concentration of OVA-specific IgE in the serum. Furthermore, the differentiation of CD4(+) T cells into Th2 was also decreased in the spleen of Fat-1 mice. Conclusion: Our results showed that an elevated level of n-3 PUFA was effective in preventing allergic airway inflammation by modulating the activation and differentiation of CD4(+) T cells in Fat-1 mice.
Publisher
WILEY-BLACKWELL
Issue Date
2014-02
Language
English
Article Type
Article
Citation

MOLECULAR NUTRITION FOOD RESEARCH, v.58, no.2, pp.365 - 375

ISSN
1613-4125
DOI
10.1002/mnfr.201300194
URI
http://hdl.handle.net/10203/318793
Appears in Collection
MSE-Journal Papers(저널논문)
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