DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Hyun-Young | ko |
dc.contributor.author | Lim, Kyu | ko |
dc.contributor.author | Lee, Sang-Myeong | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.date.accessioned | 2024-03-22T07:01:59Z | - |
dc.date.available | 2024-03-22T07:01:59Z | - |
dc.date.created | 2024-03-21 | - |
dc.date.created | 2024-03-21 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | MOLECULAR NUTRITION FOOD RESEARCH, v.58, no.2, pp.365 - 375 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/10203/318793 | - |
dc.description.abstract | Scope: It has been suggested that n-3 PUFA can be used as a preventive or therapeutic strategy to control allergic asthma. But little is known about the exact mechanisms by which n-3 PUFA modulates it. Here, the effects of elevated n-3 PUFA on ovalbumin (OVA) induced airway inflammation were investigated using Fat-1 transgenic mice that can convert n-6 PUFA to n-3 PUFA endogenously. Methods and results: First, we tested whether Fat-1 expression modulates CD4+ T-cell activation, proliferation, and differentiation in vitro and found that the Fat-1 expression attenuated all of these CD4(+) T-cell responses by suppression of T-cell receptor mediated signaling and cytokine-mediated phosphorylation of STATs. When the Fat-1 mice were sensitized and challenged with the OVA, they showed a significant decrease in the recruitment of inflammatory cells into airway, the production of Th2 cytokines, eotaxin, and mucin in the lung, and the concentration of OVA-specific IgE in the serum. Furthermore, the differentiation of CD4(+) T cells into Th2 was also decreased in the spleen of Fat-1 mice. Conclusion: Our results showed that an elevated level of n-3 PUFA was effective in preventing allergic airway inflammation by modulating the activation and differentiation of CD4(+) T cells in Fat-1 mice. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Effects of n-3 PUFA on the CD4+ type 2 helper T-cell-mediated immune responses in Fat-1 mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000337629700016 | - |
dc.identifier.scopusid | 2-s2.0-84893360618 | - |
dc.type.rims | ART | - |
dc.citation.volume | 58 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 365 | - |
dc.citation.endingpage | 375 | - |
dc.citation.publicationname | MOLECULAR NUTRITION FOOD RESEARCH | - |
dc.identifier.doi | 10.1002/mnfr.201300194 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.nonIdAuthor | Jang, Hyun-Young | - |
dc.contributor.nonIdAuthor | Lim, Kyu | - |
dc.contributor.nonIdAuthor | Lee, Sang-Myeong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Fat-1 | - |
dc.subject.keywordAuthor | n-3 PUFA | - |
dc.subject.keywordAuthor | Th2 cytokine | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | TH2 CYTOKINES | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
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