Flexible multi-modal micro-biosensor towards accurate cancer tissue targeting during biopsy process

Abstract

We report microscale flexible biosensor with multi-modal sensing capabilities (electrical impedance, pH level and glucose concentration) and application to the sensor integrated biopsy needle towards accurate cancer tissue targeting during biopsy process. The sensor is thin enough to be integrated onto the surface of biopsy needle, which allows minimal increase of needle diameter to avoid additional tissue damage during the needle insertion. Also, the sensor shows sensing performance that can cover the physical/chemical differences between cancer and normal tissues. We expect that our sensor integrated on the biopsy needle can overcome the limitation and inaccuracy of conventional image-guided biopsy process.