Method for Improving a Strain Based on In-Silico Analysis인-실리코 분석을 통한 균주개량법

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The present invention is related to a method for improving a strain on the basis of in silico analysis, in which it compares the genomic information of a target strain for producing a useful substance to the genomic information of a strain overproducing the useful substance so as to primarily screen genes unnecessary for the overproduction of the useful substance, and then to secondarily screen genes to be deleted through performing simulation with metabolic flux analysis. According to the present invention, an improved strain can be effectively constructed by the metabolic and genetic engineering approach comprising comparatively analyzing the genomic information of a target strain for producing a useful substance and the genomic information of a strain producing a large amount of the useful substance to screen candidate genes and performing in silico simulation on the screened candidate genes to select a combination of genes to be deleted, which shows an improvement in the production of the useful substance. Accordingly, the time, effort and cost required for an actual wet test can be significantly reduced.
Assignee
KAIST
Country
CC (Cocos (Keeling) Islands)
Application Date
2005-05-23
Application Number
200580045430.4
Registration Date
2011-11-30
Registration Number
101175847
URI
http://hdl.handle.net/10203/303580
Appears in Collection
CBE-Patent(특허)BS-Patent(특허)
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