Synthesis of aza-macrocycles by palladium-catalyzed dehydrative allylation = 팔라듐 촉매를 사용한 탈수 알릴 치환반응에 의한 질소헤테로거대고리의 합성

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Nitrogen-heterocycles are of great interest in the pharmaceutical industry because they are found in many biologically active compounds. The study of small rings with Nitrogen-heteroatoms is relatively well known because of the stability of this structure, but the study of macrocyclic molecules with Nitrogen-heteroatoms is still a big challenge. In this dissertation, a dehydrative substitution study of allyl alcohol and nitrogen heteromolecules by palladium-briphos catalyst was carried out. Through this allylation, aza-macrocycles could be well synthesized. Briphos ligands, which have very good π-electron acceptor properties, form complexes with palladium, and show very good reactivity to dehydrative allyl substitution reactions. The hydroxyl group was taken as a leaving group to enable double substitution using 1,4-dihydroxy-2-butene, which was conceived from allyl alcohol leaving the water. Furthermore, macrocyclic molecules having hetero atoms could be synthesized using a product made by replacing 1,4-dihydroxy-2-butene twice at the end of a nucleophile.
Advisors
Kim, Hyunwooresearcher김현우researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 2020.2,[i, 47 p. :]

Keywords

N-heterocycles▼amacrocycle ring▼apalladium▼ahydroxyl group▼adehydrative coupling▼aallyl alcohol▼aallylic substitution▼abriphos; 질소 헤테로 고리▼a거대고리분자▼a팔라듐▼a하이드록실기▼a탈수반응▼a알릴 알코올▼a알릴 치환반응▼a브리포스

URI
http://hdl.handle.net/10203/285198
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=947927&flag=dissertation
Appears in Collection
CH-Theses_Master(석사논문)
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