DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Hyunwoo | - |
dc.contributor.advisor | 김현우 | - |
dc.contributor.author | Lee, Seoyoung | - |
dc.date.accessioned | 2021-05-13T19:41:51Z | - |
dc.date.available | 2021-05-13T19:41:51Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=947927&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/285198 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2020.2,[i, 47 p. :] | - |
dc.description.abstract | Nitrogen-heterocycles are of great interest in the pharmaceutical industry because they are found in many biologically active compounds. The study of small rings with Nitrogen-heteroatoms is relatively well known because of the stability of this structure, but the study of macrocyclic molecules with Nitrogen-heteroatoms is still a big challenge. In this dissertation, a dehydrative substitution study of allyl alcohol and nitrogen heteromolecules by palladium-briphos catalyst was carried out. Through this allylation, aza-macrocycles could be well synthesized. Briphos ligands, which have very good π-electron acceptor properties, form complexes with palladium, and show very good reactivity to dehydrative allyl substitution reactions. The hydroxyl group was taken as a leaving group to enable double substitution using 1,4-dihydroxy-2-butene, which was conceived from allyl alcohol leaving the water. Furthermore, macrocyclic molecules having hetero atoms could be synthesized using a product made by replacing 1,4-dihydroxy-2-butene twice at the end of a nucleophile. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | N-heterocycles▼amacrocycle ring▼apalladium▼ahydroxyl group▼adehydrative coupling▼aallyl alcohol▼aallylic substitution▼abriphos | - |
dc.subject | 질소 헤테로 고리▼a거대고리분자▼a팔라듐▼a하이드록실기▼a탈수반응▼a알릴 알코올▼a알릴 치환반응▼a브리포스 | - |
dc.title | Synthesis of aza-macrocycles by palladium-catalyzed dehydrative allylation | - |
dc.title.alternative | 팔라듐 촉매를 사용한 탈수 알릴 치환반응에 의한 질소헤테로거대고리의 합성 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 이서영 | - |
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