Microbial production of fatty acids and derivative chemicals

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Microbial production of fatty acids and derivatives from non-edible biomass has attracted much attention as an alternative to their production from plant oils and animal fats. Fatty acids and some of their derivatives are ubiquitous metabolites synthesized for membrane biosynthesis and other metabolic purposes in microorganisms. These compounds, however, are rarely produced beyond cellular demands, frequently resulting in low titers even after metabolic engineering. Recently, more advanced metabolic engineering strategies including systems metabolic engineering allowed improved production of fatty acids and their derivatives by employing non-oleaginous and oleaginous microorganisms. Here, we review metabolic engineering strategies developed for the production of fatty acids and derivative chemicals by non-oleaginous and oleaginous microorganisms in recent years.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2020-10
Language
English
Article Type
Review
Citation

CURRENT OPINION IN BIOTECHNOLOGY, v.65, pp.129 - 141

ISSN
0958-1669
DOI
10.1016/j.copbio.2020.02.006
URI
http://hdl.handle.net/10203/275822
Appears in Collection
RIMS Journal PapersCBE-Journal Papers(저널논문)
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