Pd-Catalyzed Allylation of Imines to Access alpha-CF3-Substituted alpha-Amino Acid Derivatives

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We herein report a high yielding protocol for the direct alpha-allylation of easily accessible trifluoropyruvate-derived imines using Pd-catalysis. The reaction gives access to a variety of different alpha-allylated-alpha-CF3-amino acids in a straightforward manner, starting from commercially available trifluoropyruvate. We also provide a proof-of-concept for an enantioselective protocol (up to er = 75:25) by using chiral phosphane ligands.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2019-11
Language
English
Article Type
Article
Citation

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2019, no.42, pp.7122 - 7127

ISSN
1434-193X
DOI
10.1002/ejoc.201901272
URI
http://hdl.handle.net/10203/270075
Appears in Collection
CH-Journal Papers(저널논문)
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