AMPK links energy status to cell structure and mitosis
AMP-activated protein kinase (AMPK) is known as an important cellular energy sensor, but its in vivo role has not been fully understood. Recent studies provided surprising results that AMPK regulates cell polarity and mitosis under the control of tumour suppressor LKB1. Moreover, these newly found in vivo functions of AMPK are regulated by energy status in a cell autonomous manner. These findings provide novel insights into the physiological function of AMPK and the treatment of AMPK-related diseases such as cancer and diabetes. (c) 2007 Elsevier Inc. All rights reserved.
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Issue Date
- 2007-11
- Language
- English
- Article Type
- Review
- Keywords
ACTIVATED PROTEIN-KINASE; SERINE-THREONINE KINASE; HAPLOID INVASIVE GROWTH; PEUTZ-JEGHERS-SYNDROME; C-ELEGANS; MYOSIN-II; DROSOPHILA-MELANOGASTER; NONMUSCLE MYOSIN; LKB1 KINASE; POLARITY
- Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.362, no.4, pp.789 - 792
- ISSN
- 0006-291X
- Appears in Collection
- BS-Journal Papers(저널논문)
- Files in This Item
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