Preference for Distinct Functional Conformations of the Dopamine Transporter Alters the Relationship between Subjective Effects of Cocaine and Stimulation of Mesolimbic Dopamine
Background: Subjective effects of cocaine are mediated primarily by dopamine (DA) transporter (DAT) blockade. The present study assessed the hypothesis that different DAT conformational equilibria regulate differences in cocaine-like subjective effects and extracellular DA induced by diverse DA-uptake inhibitors (DUIs).
- Publisher
- ELSEVIER SCIENCE INC
- Issue Date
- 2014-11
- Language
- English
- Article Type
- Article
- Keywords
UPTAKE INHIBITORS; BENZTROPINE ANALOGS; EXTRACELLULAR DOPAMINE; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; SQUIRREL-MONKEYS; MONOAMINE UPTAKE; ABUSE LIABILITY; BINDING; MICRODIALYSIS
- Citation
BIOLOGICAL PSYCHIATRY, v.76, no.10, pp.802 - 809
- ISSN
- 0006-3223
- Appears in Collection
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