Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with beta-cyclodextrin
A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with beta-cyclodextrin. The complexation was confirmed by H-1 NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 2008-03
- Language
- English
- Article Type
- Article
- Keywords
TRANS-PLATINUM(II) COMPLEXES; CYTOTOXIC ACTIVITY; ANTITUMOR DRUGS; TRANS-GEOMETRY; PLATINUM; PYRIDINE; LIGANDS; ACTIVATION; CRYSTAL; POLYMER
- Citation
MOLECULAR PHARMACEUTICS, v.5, no.2, pp.358 - 363
- ISSN
- 1543-8384
- Appears in Collection
- BS-Journal Papers(저널논문)
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