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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with beta-cyclodextrin

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dc.contributor.authorHorvath, Gabrielako
dc.contributor.authorPremkumar, Thathanko
dc.contributor.authorBoztas, Aliko
dc.contributor.authorLee, Eunhyeko
dc.contributor.authorJon, Sko
dc.contributor.authorGeckeler, Kurt E.ko
dc.date.accessioned2014-12-09T01:32:42Z-
dc.date.available2014-12-09T01:32:42Z-
dc.date.created2014-08-29-
dc.date.created2014-08-29-
dc.date.issued2008-03-
dc.identifier.citationMOLECULAR PHARMACEUTICS, v.5, no.2, pp.358 - 363-
dc.identifier.issn1543-8384-
dc.identifier.urihttp://hdl.handle.net/10203/192422-
dc.description.abstractA novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with beta-cyclodextrin. The complexation was confirmed by H-1 NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectTRANS-PLATINUM(II) COMPLEXES-
dc.subjectCYTOTOXIC ACTIVITY-
dc.subjectANTITUMOR DRUGS-
dc.subjectTRANS-GEOMETRY-
dc.subjectPLATINUM-
dc.subjectPYRIDINE-
dc.subjectLIGANDS-
dc.subjectACTIVATION-
dc.subjectCRYSTAL-
dc.subjectPOLYMER-
dc.titleSupramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with beta-cyclodextrin-
dc.typeArticle-
dc.identifier.wosid000254708600017-
dc.type.rimsART-
dc.citation.volume5-
dc.citation.issue2-
dc.citation.beginningpage358-
dc.citation.endingpage363-
dc.citation.publicationnameMOLECULAR PHARMACEUTICS-
dc.contributor.localauthorJon, S-
dc.contributor.nonIdAuthorHorvath, Gabriela-
dc.contributor.nonIdAuthorPremkumar, Thathan-
dc.contributor.nonIdAuthorBoztas, Ali-
dc.contributor.nonIdAuthorLee, Eunhye-
dc.contributor.nonIdAuthorGeckeler, Kurt E.-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoranticancer drug-
dc.subject.keywordAuthorcisplatin-
dc.subject.keywordAuthorcyclodextrin-
dc.subject.keywordAuthornanoencapsulation-
dc.subject.keywordAuthorplatinum(II)-
dc.subject.keywordPlusTRANS-PLATINUM(II) COMPLEXES-
dc.subject.keywordPlusCYTOTOXIC ACTIVITY-
dc.subject.keywordPlusANTITUMOR DRUGS-
dc.subject.keywordPlusTRANS-GEOMETRY-
dc.subject.keywordPlusPLATINUM-
dc.subject.keywordPlusPYRIDINE-
dc.subject.keywordPlusLIGANDS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCRYSTAL-
dc.subject.keywordPlusPOLYMER-
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