Aberrant Development of Functional Connectivity among Resting State-Related Functional Networks in Medication-Naive ADHD Children

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Objective: The aim of this study was to investigate the compromised developmental trajectory of the functional connectivity among resting-state-related functional networks (RSFNs) in medication-naive children with attention-deficit/hyperactivity disorder (ADHD). Subjects and Methods: Using both independent component analysis and dual regression, subject-specific time courses of 12 RSFNs were extracted from both 20 medication-naive children with ADHD, and 20 age and gender-matched control children showing typical development (TDC). Both partial correlation coefficients among the 12 RSFNs and a resting-state resource allocation index (rsRAI) of the salience network (SN) were entered into multiple linear regression analysis to investigate the compromised, age-related change in medication-naive ADHD children. Finally, correlation analyses were performed between the compromised RSFN connections showing significant group-by-age interaction and rsRAI of SN or clinical variables.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2013-12
Language
English
Article Type
Article
Keywords

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; INDEPENDENT COMPONENT ANALYSIS; DEFAULT-MODE NETWORK; HUMAN BRAIN; EARLY ADULTHOOD; CHILDHOOD; MRI; METAANALYSIS; ADOLESCENCE

Citation

PLOS ONE, v.8, no.12

ISSN
1932-6203
DOI
10.1371/journal.pone.0083516
URI
http://hdl.handle.net/10203/187352
Appears in Collection
MSE-Journal Papers(저널논문)
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