Aminoglycoside antibiotics bind to the influenza A virus RNA promoter
Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.
- Publisher
- ROYAL SOC CHEMISTRY
- Issue Date
- 2012-11
- Language
- English
- Article Type
- Article
- Keywords
16S RIBOSOMAL-RNA; DECODING REGION; MESSENGER-RNA; IN-VITRO; PROTEIN; SITE; REPLICATION; INHIBITORS; RECOGNITION; CONSTRUCTS
- Citation
MOLECULAR BIOSYSTEMS, v.8, no.11, pp.2857 - 2859
- ISSN
- 1742-206X
- Appears in Collection
- CH-Journal Papers(저널논문)
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