Carbon Nanodot-Sensitized Modulation of Alzheimer's -Amyloid Self-Assembly, Disassembly, and Toxicity

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The self-assembly of amyloidogenic peptides into -sheet-rich aggregates is a general feature of many neurodegenerative diseases, including Alzheimer's disease, which signifies the need for the effective attenuation of amyloid aggregation toward alleviating amyloid-associated neurotoxicity. This study reports that photoluminescent carbon nanodots (CDs) can effectively suppress Alzheimer's -amyloid (A) self-assembly and function as a -sheet breaker disintegrating preformed A aggregates. This study synthesizes CDs using ammonium citrate through one-pot hydrothermal treatment and passivates their surface with branched polyethylenimine (bPEI). The bPEI-coated CDs (bPEI@CDs) exhibit hydrophilic and cationic surface characteristics, which interact with the negatively charged residues of A peptides, suppressing the aggregation of A peptides. Under light illumination, bPEI@CDs display a more pronounced effect on A aggregation and on the dissociation of -sheet-rich assemblies through the generation of reactive oxygen species from photoactivated bPEI@CDs. The light-triggered attenuation effect of A aggregation using a series of experiments, including photochemical and microscopic analysis, is verified. Furthermore, the cell viability test confirms the ability of photoactivated bPEI@CDs for the suppression of A-mediated cytotoxicity, indicating bPEI@CDs' potency as an effective anti-A neurotoxin agent.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2017-09
Language
English
Article Type
Article
Keywords

GRAPHENE QUANTUM DOTS; FLUORESCENT CARBON; BETA-PEPTIDE; AGGREGATION; NANOPARTICLES; MECHANISM; DISEASE; WATER; PHOTOLUMINESCENCE; PHOTOOXYGENATION

Citation

SMALL, v.13, no.34

ISSN
1613-6810
DOI
10.1002/smll.201700983
URI
http://hdl.handle.net/10203/226285
Appears in Collection
MS-Journal Papers(저널논문)
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