DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, You Jung | ko |
dc.contributor.author | Kim, Kayoung | ko |
dc.contributor.author | Lee, Byung Il | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.date.accessioned | 2017-10-23T01:27:12Z | - |
dc.date.available | 2017-10-23T01:27:12Z | - |
dc.date.created | 2017-09-25 | - |
dc.date.created | 2017-09-25 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | SMALL, v.13, no.34 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226285 | - |
dc.description.abstract | The self-assembly of amyloidogenic peptides into -sheet-rich aggregates is a general feature of many neurodegenerative diseases, including Alzheimer's disease, which signifies the need for the effective attenuation of amyloid aggregation toward alleviating amyloid-associated neurotoxicity. This study reports that photoluminescent carbon nanodots (CDs) can effectively suppress Alzheimer's -amyloid (A) self-assembly and function as a -sheet breaker disintegrating preformed A aggregates. This study synthesizes CDs using ammonium citrate through one-pot hydrothermal treatment and passivates their surface with branched polyethylenimine (bPEI). The bPEI-coated CDs (bPEI@CDs) exhibit hydrophilic and cationic surface characteristics, which interact with the negatively charged residues of A peptides, suppressing the aggregation of A peptides. Under light illumination, bPEI@CDs display a more pronounced effect on A aggregation and on the dissociation of -sheet-rich assemblies through the generation of reactive oxygen species from photoactivated bPEI@CDs. The light-triggered attenuation effect of A aggregation using a series of experiments, including photochemical and microscopic analysis, is verified. Furthermore, the cell viability test confirms the ability of photoactivated bPEI@CDs for the suppression of A-mediated cytotoxicity, indicating bPEI@CDs' potency as an effective anti-A neurotoxin agent. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | GRAPHENE QUANTUM DOTS | - |
dc.subject | FLUORESCENT CARBON | - |
dc.subject | BETA-PEPTIDE | - |
dc.subject | AGGREGATION | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MECHANISM | - |
dc.subject | DISEASE | - |
dc.subject | WATER | - |
dc.subject | PHOTOLUMINESCENCE | - |
dc.subject | PHOTOOXYGENATION | - |
dc.title | Carbon Nanodot-Sensitized Modulation of Alzheimer's -Amyloid Self-Assembly, Disassembly, and Toxicity | - |
dc.type | Article | - |
dc.identifier.wosid | 000409446800003 | - |
dc.identifier.scopusid | 2-s2.0-85024368558 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 34 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.201700983 | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | -amyloid | - |
dc.subject.keywordAuthor | carbon nanodots | - |
dc.subject.keywordAuthor | disassembly | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordPlus | GRAPHENE QUANTUM DOTS | - |
dc.subject.keywordPlus | FLUORESCENT CARBON | - |
dc.subject.keywordPlus | BETA-PEPTIDE | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | PHOTOLUMINESCENCE | - |
dc.subject.keywordPlus | PHOTOOXYGENATION | - |
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