Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

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Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.
Publisher
CELL PRESS
Issue Date
2011-08
Language
English
Article Type
Article
Keywords

ENERGY HOMEOSTASIS REGULATION; GATED POTASSIUM CHANNELS; RECTIFYING K+ CHANNELS; MELANOCORTIN PATHWAYS; AGRP NEURONS; GLUCOSE-HOMEOSTASIS; D-FENFLURAMINE; POMC NEURONS; FOOD-INTAKE; I-KACH

Citation

NEURON, v.71, no.3, pp.488 - 497

ISSN
0896-6273
DOI
10.1016/j.neuron.2011.06.012
URI
http://hdl.handle.net/10203/201677
Appears in Collection
BS-Journal Papers(저널논문)
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