DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohn, Jong-Woo | ko |
dc.contributor.author | Xu, Yong | ko |
dc.contributor.author | Jones, Juli E. | ko |
dc.contributor.author | Wickman, Kevin | ko |
dc.contributor.author | Williams, Kevin W. | ko |
dc.contributor.author | Elmquist, Joel K. | ko |
dc.date.accessioned | 2015-11-20T12:45:08Z | - |
dc.date.available | 2015-11-20T12:45:08Z | - |
dc.date.created | 2014-03-27 | - |
dc.date.created | 2014-03-27 | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | NEURON, v.71, no.3, pp.488 - 497 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/201677 | - |
dc.description.abstract | Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | ENERGY HOMEOSTASIS REGULATION | - |
dc.subject | GATED POTASSIUM CHANNELS | - |
dc.subject | RECTIFYING K+ CHANNELS | - |
dc.subject | MELANOCORTIN PATHWAYS | - |
dc.subject | AGRP NEURONS | - |
dc.subject | GLUCOSE-HOMEOSTASIS | - |
dc.subject | D-FENFLURAMINE | - |
dc.subject | POMC NEURONS | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | I-KACH | - |
dc.title | Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels | - |
dc.type | Article | - |
dc.identifier.wosid | 000293991700012 | - |
dc.identifier.scopusid | 2-s2.0-79961180328 | - |
dc.type.rims | ART | - |
dc.citation.volume | 71 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 488 | - |
dc.citation.endingpage | 497 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/j.neuron.2011.06.012 | - |
dc.contributor.localauthor | Sohn, Jong-Woo | - |
dc.contributor.nonIdAuthor | Xu, Yong | - |
dc.contributor.nonIdAuthor | Jones, Juli E. | - |
dc.contributor.nonIdAuthor | Wickman, Kevin | - |
dc.contributor.nonIdAuthor | Williams, Kevin W. | - |
dc.contributor.nonIdAuthor | Elmquist, Joel K. | - |
dc.type.journalArticle | Article | - |
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