Inositol polyphosphate multikinase signaling in the regulation of metabolism

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Inositol phosphates (IPs) act as signaling messengers to regulate various cellular processes such as growth. Inositol polyphosphate multikinase (IPMK) generates inositol tetrakis-and pentakisphosphates (IP4 and IP5), acting as a key enzyme for inositol polyphosphate biosynthesis. IPMK was initially discovered as an essential subunit of the arginine-sensing transcription complex in budding yeast. In mammals, IPMK is also known as a physiologically important phosphatidylinositol 3 kinase (PI3K) that forms phosphatidylinositol 3,4,5-trisphosphate (PIP3), which activates Akt/PKB and stimulates its signaling. Acting in a catalytically independent fashion, IPMK mediates the activation of mammalian target of rapamycin (mTOR) in response to essential amino acids. In addition, IPMK binds and modulates AMP-activated protein kinase (AMPK) signaling pathways, including those involved in hypothalamic control of food intake. These recent findings strongly suggest that IPMK is a versatile player in insulin-, nutrient-, and energy-mediated metabolism signaling networks. Agents that control IPMK functions may provide novel therapeutics in metabolic syndromes such as obesity and diabetes.
Publisher
BLACKWELL SCIENCE PUBL
Issue Date
2012-08
Language
English
Article Type
Article; Proceedings Paper
Keywords

ACTIVATED PROTEIN-KINASE; AMINO-ACIDS; SACCHAROMYCES-CEREVISIAE; RAG GTPASES; FOOD-INTAKE; NUTRIENT; MTORC1; PYROPHOSPHATES; REQUIRES; PATHWAY

Citation

NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER Book Series: Annals of the New York Academy of Sciences, v.1271, pp.68 - 74

ISSN
0077-8923
DOI
10.1111/j.1749-6632.2012.06725.x
URI
http://hdl.handle.net/10203/103010
Appears in Collection
BS-Journal Papers(저널논문)
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