DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Joo-Young | ko |
dc.contributor.author | Kim, Young-ran | ko |
dc.contributor.author | Park, Jina | ko |
dc.contributor.author | Kim, Seyun | ko |
dc.date.accessioned | 2013-03-12T17:31:35Z | - |
dc.date.available | 2013-03-12T17:31:35Z | - |
dc.date.created | 2012-10-13 | - |
dc.date.created | 2012-10-13 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER Book Series: Annals of the New York Academy of Sciences, v.1271, pp.68 - 74 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103010 | - |
dc.description.abstract | Inositol phosphates (IPs) act as signaling messengers to regulate various cellular processes such as growth. Inositol polyphosphate multikinase (IPMK) generates inositol tetrakis-and pentakisphosphates (IP4 and IP5), acting as a key enzyme for inositol polyphosphate biosynthesis. IPMK was initially discovered as an essential subunit of the arginine-sensing transcription complex in budding yeast. In mammals, IPMK is also known as a physiologically important phosphatidylinositol 3 kinase (PI3K) that forms phosphatidylinositol 3,4,5-trisphosphate (PIP3), which activates Akt/PKB and stimulates its signaling. Acting in a catalytically independent fashion, IPMK mediates the activation of mammalian target of rapamycin (mTOR) in response to essential amino acids. In addition, IPMK binds and modulates AMP-activated protein kinase (AMPK) signaling pathways, including those involved in hypothalamic control of food intake. These recent findings strongly suggest that IPMK is a versatile player in insulin-, nutrient-, and energy-mediated metabolism signaling networks. Agents that control IPMK functions may provide novel therapeutics in metabolic syndromes such as obesity and diabetes. | - |
dc.language | English | - |
dc.publisher | BLACKWELL SCIENCE PUBL | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | AMINO-ACIDS | - |
dc.subject | SACCHAROMYCES-CEREVISIAE | - |
dc.subject | RAG GTPASES | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | NUTRIENT | - |
dc.subject | MTORC1 | - |
dc.subject | PYROPHOSPHATES | - |
dc.subject | REQUIRES | - |
dc.subject | PATHWAY | - |
dc.title | Inositol polyphosphate multikinase signaling in the regulation of metabolism | - |
dc.type | Article | - |
dc.identifier.wosid | 000312488700009 | - |
dc.identifier.scopusid | 2-s2.0-84867348404 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1271 | - |
dc.citation.beginningpage | 68 | - |
dc.citation.endingpage | 74 | - |
dc.citation.publicationname | NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER Book Series: Annals of the New York Academy of Sciences | - |
dc.identifier.doi | 10.1111/j.1749-6632.2012.06725.x | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Seyun | - |
dc.contributor.nonIdAuthor | Lee, Joo-Young | - |
dc.contributor.nonIdAuthor | Kim, Young-ran | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordAuthor | inositol polyphosphate | - |
dc.subject.keywordAuthor | IPMK | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | growth | - |
dc.subject.keywordAuthor | metabolism | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | RAG GTPASES | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | NUTRIENT | - |
dc.subject.keywordPlus | MTORC1 | - |
dc.subject.keywordPlus | PYROPHOSPHATES | - |
dc.subject.keywordPlus | REQUIRES | - |
dc.subject.keywordPlus | PATHWAY | - |
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