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Choi, Minee (최민이)
조교수, Department of Brain and Cognitive Sciences(뇌인지과학과)

http://mineechoilab.kaist.ac.kr

Research Area
Development of a personalized therapeutic platform for brain disease using hiPSC, Cellular mechanism of Neurodegenerative diseases (protein misfolding), Role of mitochondrial dysfunction and oxidative stress in cell death
Co-researchers
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    NO Title, Author(s) (Publication Title, Volume Issue, Page, Issue Date)
    1
    Prediction of mechanistic subtypes of Parkinson's using patient-derived stem cell models

    D'Sa, Karishma; Evans, James R.; Virdi, Gurvir S.; et al, NATURE MACHINE INTELLIGENCE, v.5, no.8, pp.933 - 946, 2023-08

    2
    Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

    Virdi, Gurvir S.; Choi, Minee L.; Evans, James R.; et al, NPJ PARKINSONS DISEASE, v.8, no.1, 2022-11

    3
    Pathological structural conversion of alpha-synuclein at the mitochondria induces neuronal toxicity

    Choi, Minee L.; Chappard, Alexandre; Singh, Bhanu P.; et al, NATURE NEUROSCIENCE, v.25, no.9, pp.1134 - 1148, 2022-09

    4
    The Impact of Type 2 Diabetes in Parkinson's Disease

    Athauda, Dilan; Evans, James; Wernick, Anna; et al, MOVEMENT DISORDERS, v.37, no.8, pp.1612 - 1623, 2022-08

    5
    Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

    Angelova, Plamena R.; Choil, Minee L.; Berezhnov, Alexey, V; et al, CELL DEATH AND DIFFERENTIATION, v.27, no.10, pp.2781 - 2796, 2020-10

    6
    Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

    Hughes, Craig; Choi, Minee L.; Yi, Jee-Hyun; et al, COMMUNICATIONS BIOLOGY, v.3, no.1, 2020-02

    7
    Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis

    Hughes, Craig D.; Choi, Minee L.; Ryten, Mina; et al, ACTA NEUROPATHOLOGICA, v.137, no.1, pp.103 - 120, 2019-01

    8
    Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

    Choi, Minee L.; Gandhi, Sonia, FEBS JOURNAL, v.285, no.19, pp.3631 - 3644, 2018-10

    9
    Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

    Whiten, Daniel R.; Zuo, Yukun; Calo, Laura; et al, CHEMBIOCHEM, v.19, no.19, pp.2033 - 2038, 2018-10

    10
    alpha-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease

    Ludtmann, Marthe H. R.; Angelova, Plamena R.; Horrocks, Mathew H.; et al, NATURE COMMUNICATIONS, v.9, 2018-06

    11
    Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species

    Iljina, Marija; Hong, Liu; Horrocks, Mathew H.; et al, BMC BIOLOGY, v.15, 2017-07

    12
    Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

    Hall, Claire E.; Yao, Zhi; Choi, Minee; et al, CELL REPORTS, v.19, no.9, pp.1739 - 1749, 2017-05

    13
    Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

    Iljina, Marija; Tosatto, Laura; Choi, Minee L.; et al, SCIENTIFIC REPORTS, v.6, 2016-09

    14
    A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain

    Choi, Minee L.; Begeti, Faye; Barker, Roger A.; et al, HIPPOCAMPUS, v.26, no.4, pp.517 - 529, 2016-04

    15
    Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

    Iljina, Marija; Garcia, Gonzalo A.; Horrocks, Mathew H.; et al, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.113, no.9, pp.E1206 - E1215, 2016-03

    16
    The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain

    Choi, Minee; Vernon, J; Kopach, O; et al, NEUROSCIENCE LETTERS, v.594, pp.163 - 168, 2015-05

    17
    Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease

    Choi, Minee; Begeti, F.; Oh, J. H.; et al, NEUROBIOLOGY OF DISEASE, v.66, pp.19 - 27, 2014-06

    18
    A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

    Clelland, CD; Choi, Minee; Romberg, C; et al, SCIENCE, v.325, no.5937, pp.210 - 213, 2009-07

    19
    Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin

    Kim, Byung Woo; Choi, Minee; Kim, Yong-Seok; et al, CELLULAR SIGNALLING, v.20, no.4, pp.714 - 725, 2008-04
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