DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Youn-Suk | ko |
dc.contributor.author | Kim, Hong-Bae | ko |
dc.contributor.author | Kim, Seung-Hoon | ko |
dc.contributor.author | Choi, Jaekyu | ko |
dc.contributor.author | Park, Je-Kyun | ko |
dc.date.accessioned | 2013-03-11T17:58:51Z | - |
dc.date.available | 2013-03-11T17:58:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | ANALYTICAL CHEMISTRY, v.81, no.9, pp.3517 - 3522 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99811 | - |
dc.description.abstract | A microfabricated cell-based testing device for electro-chemotherapy (ECT) has been developed; it mimics a clinical electroporator with a circular needle array and maintains a similar electric field strength distribution. Until now, the performance between electroporators having two- and six-needle circular array electrodes, which are the general needle-type clinical electroporators for ECT, has not been evaluated systemically, although many studies have investigated the efficacy of ECT on cancer cells. In this study, the cell-based performance on the newly developed ECT testing device was analyzed in two- and six-electrode modes using propidium iodide and bleomycin, and the electroporation characteristics were characterized. With on-chip fluorescence-based assays, the proposed device offers time- and cost-effective experimental procedures compared with conventional assays, and the results can reflect the electric characteristics of clinical electroporators. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ELECTRIC-FIELD DISTRIBUTION | - |
dc.subject | STANDARD OPERATING PROCEDURES | - |
dc.subject | IN-VIVO ELECTROPORATION | - |
dc.subject | IRREVERSIBLE ELECTROPORATION | - |
dc.subject | TISSUE ABLATION | - |
dc.subject | THERAPY | - |
dc.subject | BLEOMYCIN | - |
dc.subject | TUMORS | - |
dc.subject | METASTASES | - |
dc.subject | CISPLATIN | - |
dc.title | Microdevice for analyzing the effect of electrochemotherapy on cancer cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000265632400043 | - |
dc.identifier.scopusid | 2-s2.0-66149131460 | - |
dc.type.rims | ART | - |
dc.citation.volume | 81 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 3517 | - |
dc.citation.endingpage | 3522 | - |
dc.citation.publicationname | ANALYTICAL CHEMISTRY | - |
dc.identifier.doi | 10.1021/ac900055r | - |
dc.contributor.localauthor | Park, Je-Kyun | - |
dc.contributor.nonIdAuthor | Kim, Hong-Bae | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ELECTRIC-FIELD DISTRIBUTION | - |
dc.subject.keywordPlus | STANDARD OPERATING PROCEDURES | - |
dc.subject.keywordPlus | IN-VIVO ELECTROPORATION | - |
dc.subject.keywordPlus | IRREVERSIBLE ELECTROPORATION | - |
dc.subject.keywordPlus | TISSUE ABLATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | BLEOMYCIN | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | METASTASES | - |
dc.subject.keywordPlus | CISPLATIN | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.