Inference of combinatorial Boolean rules of synergistic gene sets from cancer microarray datasets

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dc.contributor.authorPark, Inhoko
dc.contributor.authorLee, Kwang-Hyungko
dc.contributor.authorLee, Doheonko
dc.date.accessioned2013-03-11T17:32:50Z-
dc.date.available2013-03-11T17:32:50Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2010-06-
dc.identifier.citationBIOINFORMATICS, v.26, no.12, pp.1506 - 1512-
dc.identifier.issn1367-4803-
dc.identifier.urihttp://hdl.handle.net/10203/99742-
dc.description.abstractMotivation: Gene set analysis has become an important tool for the functional interpretation of high-throughput gene expression datasets. Moreover, pattern analyses based on inferred gene set activities of individual samples have shown the ability to identify more robust disease signatures than individual gene-based pattern analyses. Although a number of approaches have been proposed for gene set-based pattern analysis, the combinatorial influence of deregulated gene sets on disease phenotype classification has not been studied sufficiently. Results: We propose a new approach for inferring combinatorial Boolean rules of gene sets for a better understanding of cancer transcriptome and cancer classification. To reduce the search space of the possible Boolean rules, we identify small groups of gene sets that synergistically contribute to the classification of samples into their corresponding phenotypic groups (such as normal and cancer). We then measure the significance of the candidate Boolean rules derived from each group of gene sets; the level of significance is based on the class entropy of the samples selected in accordance with the rules. By applying the present approach to publicly available prostate cancer datasets, we identified 72 significant Boolean rules. Finally, we discuss several identified Boolean rules, such as the rule of glutathione metabolism (down) and prostaglandin synthesis regulation (down), which are consistent with known prostate cancer biology.-
dc.languageEnglish-
dc.publisherOXFORD UNIV PRESS-
dc.subjectRANDOM FORESTS CLASSIFICATION-
dc.subjectWIDE EXPRESSION PROFILES-
dc.subjectPROSTATE-CANCER-
dc.subjectANDROGEN RECEPTOR-
dc.subjectBREAST-CANCER-
dc.subjectDNA-REPLICATION-
dc.subjectPATHWAY-
dc.subjectNETWORKS-
dc.subjectENRICHMENT-
dc.subjectCELLS-
dc.titleInference of combinatorial Boolean rules of synergistic gene sets from cancer microarray datasets-
dc.typeArticle-
dc.identifier.wosid000278689000056-
dc.identifier.scopusid2-s2.0-77954199810-
dc.type.rimsART-
dc.citation.volume26-
dc.citation.issue12-
dc.citation.beginningpage1506-
dc.citation.endingpage1512-
dc.citation.publicationnameBIOINFORMATICS-
dc.identifier.doi10.1093/bioinformatics/btq207-
dc.contributor.localauthorLee, Kwang-Hyung-
dc.contributor.localauthorLee, Doheon-
dc.contributor.nonIdAuthorPark, Inho-
dc.type.journalArticleArticle-
dc.subject.keywordPlusRANDOM FORESTS CLASSIFICATION-
dc.subject.keywordPlusWIDE EXPRESSION PROFILES-
dc.subject.keywordPlusPROSTATE-CANCER-
dc.subject.keywordPlusANDROGEN RECEPTOR-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusDNA-REPLICATION-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusNETWORKS-
dc.subject.keywordPlusENRICHMENT-
dc.subject.keywordPlusCELLS-
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