DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Kyungsun | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2013-03-11T16:37:06Z | - |
dc.date.available | 2013-03-11T16:37:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | CANCER RESEARCH AND TREATMENT, v.41, no.1, pp.36 - 44 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99616 | - |
dc.description.abstract | Purpose ; Malignant astrocytomas are among the commonest primary brain tumors and they have a grave prognosis, and so there is an urgent need to develop effective treatment. In this study, we investigated the molecular mechanisms that are responsible for the anti-tumor effect of ginsenosides on human astrocytoma cells. Materials and Methods ; We tested 13 different ginsenosides for their anti-tumor effect on human malignant astrocytoma cells in conjunction with Fas stimulation. In addition, the cell signaling pathways were explored by using pharmacological inhibitors and performing immunoblot analysis. DCF-DA staining and antioxidant experiments were performed to investigate the role of reactive oxygen species as one of the apoptosis-inducing mechanisms. Results ; Among the 13 different ginsenoside metabolites, compound K and Rh2 induced apoptotic cell death of the astrocytoma cells in a caspase- and p38 MAPK-dependent manner, yet the same treatment had no cytotoxic effect on the primary cultured human astrocytes. Combined treatment with ginsenosides and Fas ligand showed a synergistic cytotoxic effect, which was mediated by the reduction of intracellular reactive oxygen species. Conclusion ; These results suggest that ginsenoside metabolites in combination with Fas ligand may provide a new strategy to treat malignant astrocytomas, which are tumors that are quite resistant to conventional anti-cancer treatment. | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.title | Proapoptotic Ginsenosides Compound K and Rh2 Enhance Fas-induced Cell Death of Human Astrocytoma Cells through Distinct Apoptotic Signaling Pathways | - |
dc.type | Article | - |
dc.identifier.wosid | 000208486400006 | - |
dc.type.rims | ART | - |
dc.citation.volume | 41 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 36 | - |
dc.citation.endingpage | 44 | - |
dc.citation.publicationname | CANCER RESEARCH AND TREATMENT | - |
dc.identifier.doi | 10.4143/crt.2009.41.1.36 | - |
dc.identifier.kciid | ART001332017 | - |
dc.contributor.localauthor | Choi, Kyungsun | - |
dc.contributor.nonIdAuthor | Choi, Chulhee | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Ginsenoside | - |
dc.subject.keywordAuthor | Fas | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Astrocytoma | - |
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