DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jong-Young | ko |
dc.contributor.author | Lee, Su-Hee | ko |
dc.contributor.author | Na, Hyon-Bin | ko |
dc.contributor.author | An, Kwang-Jin | ko |
dc.contributor.author | Hyeon, Taeg-Hwan | ko |
dc.contributor.author | Seo, Tae-Seok | ko |
dc.date.accessioned | 2013-03-11T15:53:17Z | - |
dc.date.available | 2013-03-11T15:53:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | BIOPROCESS AND BIOSYSTEMS ENGINEERING, v.33, pp.21 - 30 | - |
dc.identifier.issn | 1615-7591 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99527 | - |
dc.description.abstract | In this study, we present in vitro cytotoxicity of iron oxide (Fe(3)O(4)) and manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 mu g/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells). The surface of nanoparticles is modified with polyethyleneglycol-derivatized phospholipid to enhance the biocompatibility, water-solubility, and stability under an aqueous media. While the cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 mu g/ml, MnO nanoparticle represented higher level of toxicity than those of Fe(3)O(4) and the commercial medical contrast reagent, Feridex after 2 and 4 day incubation time. However, the cytotoxicity of Fe(3)O(4) is equivalent or better than Feridex based on the live/dead cell viability assay. The engineered MnO and Fe(3)O(4) exhibited excellent stability compared with Feridex for a prolonged incubation time. | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | MAGNETIC NANOPARTICLES | - |
dc.subject | MONODISPERSE NANOCRYSTALS | - |
dc.subject | COLORIMETRIC ASSAY | - |
dc.subject | CYTO-TOXICITY | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | PROLIFERATION | - |
dc.subject | NANOTOXICITY | - |
dc.subject | RELEASE | - |
dc.subject | VIVO | - |
dc.title | In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines | - |
dc.type | Article | - |
dc.identifier.wosid | 000272910600003 | - |
dc.identifier.scopusid | 2-s2.0-76849101781 | - |
dc.type.rims | ART | - |
dc.citation.volume | 33 | - |
dc.citation.beginningpage | 21 | - |
dc.citation.endingpage | 30 | - |
dc.citation.publicationname | BIOPROCESS AND BIOSYSTEMS ENGINEERING | - |
dc.identifier.doi | 10.1007/s00449-009-0354-5 | - |
dc.contributor.localauthor | Seo, Tae-Seok | - |
dc.contributor.nonIdAuthor | Na, Hyon-Bin | - |
dc.contributor.nonIdAuthor | An, Kwang-Jin | - |
dc.contributor.nonIdAuthor | Hyeon, Taeg-Hwan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Water-dispersible Fe3O4 and MnO nanoparticle | - |
dc.subject.keywordAuthor | Magnetic resonance imaging contrast agents | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Nanotoxicology | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | MONODISPERSE NANOCRYSTALS | - |
dc.subject.keywordPlus | COLORIMETRIC ASSAY | - |
dc.subject.keywordPlus | CYTO-TOXICITY | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | NANOTOXICITY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | VIVO | - |
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