DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koldobskiy, Michael A. | ko |
dc.contributor.author | Chakraborty, Anutosh | ko |
dc.contributor.author | Werner, J. Kent, Jr. | ko |
dc.contributor.author | Snowman, Adele M. | ko |
dc.contributor.author | Juluri, Krishna R. | ko |
dc.contributor.author | Vandiver, M. Scott | ko |
dc.contributor.author | Kim, Seyun | ko |
dc.contributor.author | Heletz, Shira | ko |
dc.contributor.author | Snyder, Solomon H. | ko |
dc.date.accessioned | 2013-03-11T12:14:56Z | - |
dc.date.available | 2013-03-11T12:14:56Z | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.49, pp.20947 - 20951 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99290 | - |
dc.description.abstract | Inositol pyrophosphates have been implicated in numerous biological processes. Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death. The tumor suppressor p53 responds to genotoxic stress by engaging a transcriptional program leading to cell-cycle arrest or apoptosis. We demonstrate that IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | OVARIAN-CARCINOMA CELLS | - |
dc.subject | HUMAN CANCER-CELLS | - |
dc.subject | ANTICANCER AGENTS | - |
dc.subject | TELOMERE LENGTH | - |
dc.subject | GENE DELETION | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | P53 | - |
dc.subject | PYROPHOSPHATES | - |
dc.subject | PUMA | - |
dc.subject | FAMILY | - |
dc.title | p53-mediated apoptosis requires inositol hexakisphosphate kinase-2 | - |
dc.type | Article | - |
dc.identifier.wosid | 000285050800021 | - |
dc.identifier.scopusid | 2-s2.0-78649955044 | - |
dc.type.rims | ART | - |
dc.citation.volume | 107 | - |
dc.citation.issue | 49 | - |
dc.citation.beginningpage | 20947 | - |
dc.citation.endingpage | 20951 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1015671107 | - |
dc.contributor.localauthor | Kim, Seyun | - |
dc.contributor.nonIdAuthor | Koldobskiy, Michael A. | - |
dc.contributor.nonIdAuthor | Chakraborty, Anutosh | - |
dc.contributor.nonIdAuthor | Werner, J. Kent, Jr. | - |
dc.contributor.nonIdAuthor | Snowman, Adele M. | - |
dc.contributor.nonIdAuthor | Juluri, Krishna R. | - |
dc.contributor.nonIdAuthor | Vandiver, M. Scott | - |
dc.contributor.nonIdAuthor | Heletz, Shira | - |
dc.contributor.nonIdAuthor | Snyder, Solomon H. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | OVARIAN-CARCINOMA CELLS | - |
dc.subject.keywordPlus | HUMAN CANCER-CELLS | - |
dc.subject.keywordPlus | ANTICANCER AGENTS | - |
dc.subject.keywordPlus | TELOMERE LENGTH | - |
dc.subject.keywordPlus | GENE DELETION | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | PYROPHOSPHATES | - |
dc.subject.keywordPlus | PUMA | - |
dc.subject.keywordPlus | FAMILY | - |
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