DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sen, Nilkantha | ko |
dc.contributor.author | Paul, Bindu D. | ko |
dc.contributor.author | Gadalla, Moataz M. | ko |
dc.contributor.author | Mustafa, Asif K. | ko |
dc.contributor.author | Sen, Tanusree | ko |
dc.contributor.author | Xu, Risheng | ko |
dc.contributor.author | Kim, Seyun | ko |
dc.contributor.author | Snyder, Solomon H. | ko |
dc.date.accessioned | 2013-03-11T12:12:43Z | - |
dc.date.available | 2013-03-11T12:12:43Z | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | MOLECULAR CELL, v.45, no.1, pp.13 - 24 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99286 | - |
dc.description.abstract | Nuclear factor kappa B (NF kappa B) is an antiapoptotic transcription factor. We show that the antiapoptotic actions of NF-kappa B are mediated by hydrogen sulfide (H(2)S) synthesized by cystathionine gamma-lyase (CSE). TNF-alpha treatment triples H(2)S generation by stimulating binding of SP1 to the CSE promoter. H(2)S generated by CSE stimulates DNA binding and gene activation of NF-kappa B, processes that are abolished in CSE-deleted mice. As CSE deletion leads to decreased glutathione levels, resultant oxidative stress may contribute to alterations in CSE mutant mice. H(2)S acts by sulfhydrating the p65 subunit of NF-kappa B at cysteine-38, which promotes its binding to the coactivator ribosomal protein S3 (RPS3). Sulfhydration of p65 predominates early after TNF-alpha treatment, then declines and is succeeded by a reciprocal enhancement of p65 nitrosylation. In CSE mutant mice, antiapoptotic influences of NF-kappa B are markedly diminished. Thus, sulfhydration of NF-kappa B appears to be a physiologic determinant of its antiapoptotic transcriptional activity. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | CYSTATHIONINE GAMMA-LYASE | - |
dc.subject | PROTEIN S-NITROSYLATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | REACTIVITY | - |
dc.subject | CYSTEINES | - |
dc.subject | APOPTOSIS | - |
dc.subject | OXIDATION | - |
dc.subject | SUBUNIT | - |
dc.subject | KINASE | - |
dc.subject | DEATH | - |
dc.title | Hydrogen Sulfide-Linked Sulfhydration of NF-kappa B Mediates Its Antiapoptotic Actions | - |
dc.type | Article | - |
dc.identifier.wosid | 000299301300006 | - |
dc.identifier.scopusid | 2-s2.0-84862909327 | - |
dc.type.rims | ART | - |
dc.citation.volume | 45 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 13 | - |
dc.citation.endingpage | 24 | - |
dc.citation.publicationname | MOLECULAR CELL | - |
dc.identifier.doi | 10.1016/j.molcel.2011.10.021 | - |
dc.contributor.localauthor | Kim, Seyun | - |
dc.contributor.nonIdAuthor | Sen, Nilkantha | - |
dc.contributor.nonIdAuthor | Paul, Bindu D. | - |
dc.contributor.nonIdAuthor | Gadalla, Moataz M. | - |
dc.contributor.nonIdAuthor | Mustafa, Asif K. | - |
dc.contributor.nonIdAuthor | Sen, Tanusree | - |
dc.contributor.nonIdAuthor | Xu, Risheng | - |
dc.contributor.nonIdAuthor | Snyder, Solomon H. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CYSTATHIONINE GAMMA-LYASE | - |
dc.subject.keywordPlus | PROTEIN S-NITROSYLATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | REACTIVITY | - |
dc.subject.keywordPlus | CYSTEINES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | SUBUNIT | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | DEATH | - |
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