DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Yong An | ko |
dc.contributor.author | Peterson, Bradley S. | ko |
dc.contributor.author | Yoon, Sujung J. | ko |
dc.contributor.author | Cho, Sung-Nam | ko |
dc.contributor.author | Chai, Sukhi | ko |
dc.contributor.author | Jeong, Jaeseung | ko |
dc.contributor.author | Kim, Dai Jin | ko |
dc.date.accessioned | 2013-03-11T09:25:38Z | - |
dc.date.available | 2013-03-11T09:25:38Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | DRUG AND ALCOHOL DEPENDENCE, v.111, no.1-2, pp.155 - 160 | - |
dc.identifier.issn | 0376-8716 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98906 | - |
dc.description.abstract | Objective: The aim of this study was to examine disturbances in regional cerebral blood flow (rCBF) associated with methamphetamine abuse. Methods: Using Single Photon Emission Computed Tomography (SPELT), rCBF was measured in 20 men who had previously injected methamphetamine intravenously for over 30 months and who were now abstinent for a minimum of 9 months and for an average of 2 years. Values were compared with those in 12 healthy men who had never injected methamphetamine. Results: While rCBF was significantly and disproportionately reduced in subcortical and dorsal cortical brain regions, including the striatum, thalamus, cingulum, mesiodorsal prefrontal cortex, and pons (all t's > 8.3 after global normalization, corrected p's < 0.001), whole brain CBF was also significantly reduced in the former methamphetamine users. Binge use of methamphetamine is associated with long-term changes in both global and regional blood flows, likely representing severe and enduring neural toxicity of monoaminergic neurotransmitter systems in the brain, producing a pattern of hypoperfusion that resembles patterns reported previously for persons with atypical Parkinson's disease. Conclusions: These findings suggest that methamphetamine abusers may be possibly at increased risk for neurodegenerative diseases later in life. (C) 2010 Published by Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | CEREBRAL-BLOOD-FLOW | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | ABSTINENT METHAMPHETAMINE | - |
dc.subject | INDUCED NEUROTOXICITY | - |
dc.subject | STRIATAL GLUTAMATE | - |
dc.subject | GLOBAL SIGNAL | - |
dc.subject | DOPAMINE | - |
dc.subject | ABUSERS | - |
dc.subject | BRAIN | - |
dc.subject | AMPHETAMINE | - |
dc.title | In vivo evidence for long-term CNS toxicity, associated with chronic binge use of methamphetamine | - |
dc.type | Article | - |
dc.identifier.wosid | 000282476700022 | - |
dc.identifier.scopusid | 2-s2.0-77956189166 | - |
dc.type.rims | ART | - |
dc.citation.volume | 111 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 155 | - |
dc.citation.endingpage | 160 | - |
dc.citation.publicationname | DRUG AND ALCOHOL DEPENDENCE | - |
dc.identifier.doi | 10.1016/j.drugalcdep.2010.04.005 | - |
dc.contributor.localauthor | Jeong, Jaeseung | - |
dc.contributor.nonIdAuthor | Chung, Yong An | - |
dc.contributor.nonIdAuthor | Peterson, Bradley S. | - |
dc.contributor.nonIdAuthor | Yoon, Sujung J. | - |
dc.contributor.nonIdAuthor | Cho, Sung-Nam | - |
dc.contributor.nonIdAuthor | Chai, Sukhi | - |
dc.contributor.nonIdAuthor | Kim, Dai Jin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Methamphetamine | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.subject.keywordAuthor | Cerebral blood flow | - |
dc.subject.keywordAuthor | SPECT | - |
dc.subject.keywordAuthor | SPM | - |
dc.subject.keywordPlus | CEREBRAL-BLOOD-FLOW | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | ABSTINENT METHAMPHETAMINE | - |
dc.subject.keywordPlus | INDUCED NEUROTOXICITY | - |
dc.subject.keywordPlus | STRIATAL GLUTAMATE | - |
dc.subject.keywordPlus | GLOBAL SIGNAL | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | ABUSERS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | AMPHETAMINE | - |
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