DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gu, Luo | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.contributor.author | Duong, Kim H. | ko |
dc.contributor.author | Ruoslahti, Erkki | ko |
dc.contributor.author | Sailor, Michael J. | ko |
dc.date.accessioned | 2013-03-11T07:45:45Z | - |
dc.date.available | 2013-03-11T07:45:45Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | SMALL, v.6, no.22, pp.2546 - 2552 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98688 | - |
dc.description.abstract | Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with sttperparamagnetic iron oxide nanoparticles and the anti-cancer drug doxorubicin. The drug-containing particles are delivered to human cervical cancer (HeLa) cells in vitro, under the guidance of a magnetic field. The high concentration of particles in the proximity of the magnetic field results in a high concentration of drug being released in that region of the Petri dish, and localized cell death is confirmed by cellular viability assay (Calcein AM). | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | CORNEAL EPITHELIAL-CELLS | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | MESOPOROUS SILICON | - |
dc.subject | AQUEOUS-SOLUTION | - |
dc.subject | FLUORESCENT | - |
dc.subject | NANOPARTICLES | - |
dc.subject | NANOCRYSTALS | - |
dc.subject | RELEASE | - |
dc.subject | DOXORUBICIN | - |
dc.subject | MICROBEADS | - |
dc.title | Magnetic Luminescent Porous Silicon Microparticles for Localized Delivery of Molecular Drug Payloads | - |
dc.type | Article | - |
dc.identifier.wosid | 000285164600010 | - |
dc.identifier.scopusid | 2-s2.0-78649654363 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 22 | - |
dc.citation.beginningpage | 2546 | - |
dc.citation.endingpage | 2552 | - |
dc.citation.publicationname | SMALL | - |
dc.identifier.doi | 10.1002/smll.201000841 | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.nonIdAuthor | Gu, Luo | - |
dc.contributor.nonIdAuthor | Duong, Kim H. | - |
dc.contributor.nonIdAuthor | Ruoslahti, Erkki | - |
dc.contributor.nonIdAuthor | Sailor, Michael J. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CORNEAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | MESOPOROUS SILICON | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTION | - |
dc.subject.keywordPlus | FLUORESCENT | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | MICROBEADS | - |
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