DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Jennifer Hyunjong | ko |
dc.contributor.author | Shin, Dong Wook | ko |
dc.contributor.author | Noh, Minsoo | ko |
dc.date.accessioned | 2013-03-11T07:11:21Z | - |
dc.date.available | 2013-03-11T07:11:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | BIOCHEMICAL PHARMACOLOGY, v.77, no.12, pp.1835 - 1844 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98619 | - |
dc.description.abstract | The immune system is closely linked to human metabolic diseases. Serum levels of IL-6 increase with obesity and insulin resistance. Not only does IL-6 decrease the insulin sensitivity of human cells such as adipocytes, but it also regulates the lineage commitment of naive T cells into interleukin (IL)-17A-producing CD4(+) T (Th17) cells. Although IL-17A exerts a variety of effects on somatic tissues, its functional role in human adipocytes has not been identified. In this work, we show that IL-17A inhibits adipocyte differentiation in human bone marrow mesenchymal stem cells (hBM-MSCs), while promoting lipolysis of differentiated adipocytes. We find that IL-17A increases both mRNA and protein secretion of IL-6 and IL-8 during adipocyte differentiation in hBM-MSCs. IL-17A up-regulates cyclooxygenase (COX)-2 gene expression and thereby increases the level of prostaglandin (PG) E(2) in differentiated adipocyes. The suppression of anti-adipogenic PGE(2) by COX inhibitors such as aspirin and NS-398 partially blocked the effect of IL-17A on adipocyte differentiation in hBM-MSCs. Therefore, IL-17A exhibits its inhibitory effect in part via the COX-2 induction in differentiated adipocytes. In addition, treatment with anti-IL-17A antibody neutralizes IL-17A-mediated effects on adipocyte differentiation and function. These results Suggest that IL-17A plays a regulatory role in both the metabolic and inflammatory processes of human adipocytes, similar to other pro-inflammatory cytokines such as IL-1, IFN-gamma, and TNF alpha. (c) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000266084600010 | - |
dc.identifier.scopusid | 2-s2.0-67349178585 | - |
dc.type.rims | ART | - |
dc.citation.volume | 77 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1835 | - |
dc.citation.endingpage | 1844 | - |
dc.citation.publicationname | BIOCHEMICAL PHARMACOLOGY | - |
dc.identifier.doi | 10.1016/j.bcp.2009.03.008 | - |
dc.contributor.localauthor | Shin, Jennifer Hyunjong | - |
dc.contributor.nonIdAuthor | Shin, Dong Wook | - |
dc.contributor.nonIdAuthor | Noh, Minsoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | IL-17A | - |
dc.subject.keywordAuthor | Metabolic syndromes | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Adipocyte differentiation | - |
dc.subject.keywordAuthor | Human bone marrow mesenchymal stem cells | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | HELPER T-CELLS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | TH17 CELLS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | RECEPTOR COMPLEX | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | FAMILY-MEMBERS | - |
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