DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yuhan | ko |
dc.contributor.author | Chung, Hyun Jung | ko |
dc.contributor.author | Yeo, Sangho | ko |
dc.contributor.author | Ahn, Cheol-Hee | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.contributor.author | Messersmith, Phillip B | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2013-03-11T01:32:37Z | - |
dc.date.available | 2013-03-11T01:32:37Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | SOFT MATTER, v.6, no.5, pp.977 - 983 | - |
dc.identifier.issn | 1744-683X | - |
dc.identifier.uri | http://hdl.handle.net/10203/97930 | - |
dc.description.abstract | Hyaluronic acid (HA) hydrogels are widely pursued as tissue regenerative and drug delivery materials due to their excellent biocompatibility and biodegradability. Inspired by mussel adhesion, we report here a novel class of thermo-sensitive and injectable HA/Pluronic F127 composite tissue-adhesive hydrogels applicable for various biomedical applications. HA conjugated with dopamine (HA-DN) was mixed with thiol end-capped Pluronic F127 copolymer (Plu-SH) to produce a lightly cross-linked HA/Pluronic composite gel structure based on Michael-type catechol-thiol addition reaction. The HA/Pluronic hydrogels exhibited temperature-dependent sol-gel phase transition behaviors different from Pluronic hydrogels. Rheological studies showed that the sol-gel transitions were rapid and reversible in response to temperature. The HA/Pluronic hydrogels could be injected in vivo in a sol state at room temperature using a syringe, but immediately became a robust gel state at body temperature. The in situ formed hydrogels exhibited excellent tissue-adhesion properties with superior in vivo gel stability and are potentially useful for drug and cell delivery. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | HUMAN GROWTH-HORMONE | - |
dc.subject | MULTIBLOCK COPOLYMERS | - |
dc.subject | ACID | - |
dc.subject | DELIVERY | - |
dc.subject | DOPAMINE | - |
dc.subject | DEGRADATION | - |
dc.subject | NETWORKS | - |
dc.subject | BEHAVIOR | - |
dc.subject | BRAIN | - |
dc.subject | PH | - |
dc.title | Thermo-sensitive, injectable, and tissue adhesive sol-gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction | - |
dc.type | Article | - |
dc.identifier.wosid | 000274830500021 | - |
dc.identifier.scopusid | 2-s2.0-77249178389 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 977 | - |
dc.citation.endingpage | 983 | - |
dc.citation.publicationname | SOFT MATTER | - |
dc.identifier.doi | 10.1039/b919944f | - |
dc.contributor.localauthor | Chung, Hyun Jung | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Ahn, Cheol-Hee | - |
dc.contributor.nonIdAuthor | Messersmith, Phillip B | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HUMAN GROWTH-HORMONE | - |
dc.subject.keywordPlus | MULTIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | NETWORKS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | PH | - |
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