DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Hoo-Geun | ko |
dc.contributor.author | Oh, Sang-Phil | ko |
dc.contributor.author | Oh, Hyun-Jung | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2013-03-09T21:00:12Z | - |
dc.date.available | 2013-03-09T21:00:12Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.391, no.1, pp.969 - 973 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/97446 | - |
dc.description.abstract | The tumor suppressor, RASSF2 (Ras association domain family 2), is frequently downregulated in a number of cancers Although exogenously expressed RASSF2 induces apoptotic cell death, the precise roles of RASSF2 under pro-apoptotic conditions remain largely unknown Here. we demonstrate that MST1 (mammalian sterile 20-like kinase 1) regulates RASSF2 protein stability Knockdown of MST1 in cancer cells markedly destabilizes RASSF2, and Mst1-deficient mice show reduced Rassf2 protein levels in several organs. Conversely. RASSF2 activates MsT1 kinase activity through formation of a RASSF2-MST1 complex, which inhibits the MST-FOXO3 signaling pathway RASSF2 also engages the JNK pathway and induces apoptosis in an MST1-independent manner. Collectively, these findings indicate that MST1 is a major determinant of RASSF2 protein stability. and suggest that RASSF2 acts in a complex manner that extends beyond simple protein-protein association to play an important role in MST1 regulation (C) 2009 Published by Elsevier Inc | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | EPIGENETIC INACTIVATION | - |
dc.subject | PROMOTER METHYLATION | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | HIPPO PATHWAY | - |
dc.subject | APOPTOSIS | - |
dc.subject | EFFECTOR | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | ACTIVATION | - |
dc.subject | GENE | - |
dc.title | Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity | - |
dc.type | Article | - |
dc.identifier.wosid | 000273624500171 | - |
dc.identifier.scopusid | 2-s2.0-72949094426 | - |
dc.type.rims | ART | - |
dc.citation.volume | 391 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 969 | - |
dc.citation.endingpage | 973 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.11.175 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | RASSF2 | - |
dc.subject.keywordAuthor | MST1 | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordPlus | EPIGENETIC INACTIVATION | - |
dc.subject.keywordPlus | PROMOTER METHYLATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.