DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Sung-Young | ko |
dc.contributor.author | Yang, Hee-Won | ko |
dc.contributor.author | Kim, Jeong-Rae | ko |
dc.contributor.author | Heo, Won-Do | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2013-03-09T20:36:18Z | - |
dc.date.available | 2013-03-09T20:36:18Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | JOURNAL OF CELL SCIENCE (Featured Cover Article 선정. 조선일보, 한국경제 등 10개 일간지에 보도됨.), v.124, no.1, pp.82 - 90 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97417 | - |
dc.description.abstract | Regulator of calcineurin 1 (RCAN1) is a key regulator of the calcineurin-NFAT signaling network in organisms ranging from yeast to human, but its functional role is still under debate because different roles of RCAN1 have been suggested under various experimental conditions. To elucidate the mechanisms underlying the RCAN1 regulatory system, we used a systems approach by combining single-cell experimentation with in silico simulations. In particular, we found that the nuclear export of GSK3 beta, which switches on the facilitative role of RCAN1 in the calcineurin-NFAT signaling pathway, is promoted by PI3K signaling. Based on this, along with integrated information from previous experiments, we developed a mathematical model in which the functional role of RCAN1 changes in a dose-dependent manner: RCAN1 functions as an inhibitor when its levels are low, but as a facilitator when its levels are high. Furthermore, we identified a hidden incoherent regulation switch that mediates this role change, which entails negative regulation through RCAN1 binding to calcineurin and positive regulation through sequential phosphorylation of RCAN1. | - |
dc.language | English | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.title | A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network | - |
dc.type | Article | - |
dc.identifier.wosid | 000285242200010 | - |
dc.identifier.scopusid | 2-s2.0-78651092705 | - |
dc.type.rims | ART | - |
dc.citation.volume | 124 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 82 | - |
dc.citation.endingpage | 90 | - |
dc.citation.publicationname | JOURNAL OF CELL SCIENCE (Featured Cover Article 선정. 조선일보, 한국경제 등 10개 일간지에 보도됨.) | - |
dc.contributor.localauthor | Heo, Won-Do | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Shin, Sung-Young | - |
dc.contributor.nonIdAuthor | Kim, Jeong-Rae | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Systems biology | - |
dc.subject.keywordAuthor | Calcineurin-NFAT signaling pathway | - |
dc.subject.keywordAuthor | RCAN1 | - |
dc.subject.keywordAuthor | Incoherent regulation switch | - |
dc.subject.keywordAuthor | Cardiac hypertrophy | - |
dc.subject.keywordAuthor | Mathematical modeling | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3 | - |
dc.subject.keywordPlus | CARDIAC MYOCYTES | - |
dc.subject.keywordPlus | CARDIOMYOCYTE HYPERTROPHY | - |
dc.subject.keywordPlus | INTERACTING PROTEIN-1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INHIBITION | - |
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