DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Hyejin | ko |
dc.contributor.author | Zheng, Long Tai | ko |
dc.contributor.author | Lee, Shinrye | ko |
dc.contributor.author | Lee, Won-Ha | ko |
dc.contributor.author | Park, Jae-Yong | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Lee, Myung-Shik | ko |
dc.contributor.author | Suk, Kyoungho | ko |
dc.date.accessioned | 2013-03-09T20:35:25Z | - |
dc.date.available | 2013-03-09T20:35:25Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | EXPERIMENTAL CELL RESEARCH, v.317, no.14, pp.2007 - 2018 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97416 | - |
dc.description.abstract | Small G protein superfamily consists of more than 150 members, and is classified into six families: the Ras, Rho, Rab, Art, Ran, and RGK families. They regulate a wide variety of cell functions such as cell proliferation/differentiation, cytoskeletal reorganization, vesicle trafficking, nucleocytoplasmic transport and microtubule organization. The small G proteins have also been shown to regulate cell death/survival and cell shape. In this study, we compared the role of representative members of the six families of small G proteins in cell migration and cell death/survival, two cellular phenotypes that are associated with inflammation, tumorigenesis, and metastasis. Our results show that small G proteins of the six families differentially regulate cell death and cell cycle distribution. In particular, our results indicate that Rho family of small G proteins is antiapoptotic. Ras, Rho, and Ran families promoted cell migration. There was no significant correlation between the cell death- and cell migration-regulating activities of the small G proteins. Nevertheless. RalA was not only cytoprotective against multiple chemotherapeutic drugs, but also promigratory inducing stress fiber formation, which was accompanied by the activation of Akt and Erk pathways. Our study provides a framework for further systematic investigation of small G proteins in the perspectives of cell death/survival and motility in inflammation and cancer. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER INC | - |
dc.title | Comparative analysis of the role of small G proteins in cell migration and cell death: Cytoprotective and promigratory effects of RalA | - |
dc.type | Article | - |
dc.identifier.wosid | 000292944400005 | - |
dc.identifier.scopusid | 2-s2.0-79960102252 | - |
dc.type.rims | ART | - |
dc.citation.volume | 317 | - |
dc.citation.issue | 14 | - |
dc.citation.beginningpage | 2007 | - |
dc.citation.endingpage | 2018 | - |
dc.citation.publicationname | EXPERIMENTAL CELL RESEARCH | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Jeon, Hyejin | - |
dc.contributor.nonIdAuthor | Zheng, Long Tai | - |
dc.contributor.nonIdAuthor | Lee, Shinrye | - |
dc.contributor.nonIdAuthor | Lee, Won-Ha | - |
dc.contributor.nonIdAuthor | Park, Jae-Yong | - |
dc.contributor.nonIdAuthor | Lee, Myung-Shik | - |
dc.contributor.nonIdAuthor | Suk, Kyoungho | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Small G protein | - |
dc.subject.keywordAuthor | Cell death | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Cell migration | - |
dc.subject.keywordAuthor | RalA | - |
dc.subject.keywordPlus | MAPK SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | GTP-BINDING PROTEINS | - |
dc.subject.keywordPlus | RHO-GTPASES | - |
dc.subject.keywordPlus | THERAPEUTIC TARGETS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CYCLOHEXIMIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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