The expanding reach of the GAL4/UAS system into the behavioral neurobiology of Drosophila

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dc.contributor.authorJones, Walton Dko
dc.date.accessioned2013-03-09T19:13:58Z-
dc.date.available2013-03-09T19:13:58Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2009-11-
dc.identifier.citationBMB REPORTS, v.42, no.11, pp.705 - 712-
dc.identifier.issn1976-6696-
dc.identifier.urihttp://hdl.handle.net/10203/97242-
dc.description.abstractOur understanding of the relationships between genes, brains, and behaviors has changed a lot since the first behavioral mutants were isolated in the fly bottles of the Benzer lab at Caltech (1), but Drosophila is still an excellent model system for studying the neurobiology of behavior. Recent advances provide an unprecedented level of control over fly neural circuits. Efforts are underway to add to existing GAL4-driver lines that pen-nit exogenous expression of genetic tools in small populations of neurons. Combining these driver lines with a variety of inducible UAS lines permits the visualization of neuronal morphology, connectivity, and activity. These driver lines also make it possible to specifically ablate, inhibit, or activate subsets of neurons and assess their roles in the generation of behavioral responses. Here, I will briefly review the extensive arsenal now available to drosophilists for investigating the neuronal control of behavior. [BMB reports 2009; 42(11): 705-712]-
dc.languageEnglish-
dc.publisherKorean Society Biochemistry & Molecular Biology-
dc.subjectANTENNAL LOBE-
dc.subjectSYNAPTIC-TRANSMISSION-
dc.subjectNERVOUS-SYSTEM-
dc.subjectFLUORESCENT PROTEINS-
dc.subjectTARGETED EXPRESSION-
dc.subjectGENETIC APPROACH-
dc.subjectNEURAL PATHWAYS-
dc.subjectSENSORY NEURONS-
dc.subjectMUSHROOM BODIES-
dc.subjectFLY BRAIN-
dc.titleThe expanding reach of the GAL4/UAS system into the behavioral neurobiology of Drosophila-
dc.typeArticle-
dc.identifier.wosid000272346200002-
dc.identifier.scopusid2-s2.0-73449119315-
dc.type.rimsART-
dc.citation.volume42-
dc.citation.issue11-
dc.citation.beginningpage705-
dc.citation.endingpage712-
dc.citation.publicationnameBMB REPORTS-
dc.contributor.localauthorJones, Walton D-
dc.type.journalArticleReview-
dc.subject.keywordAuthorDrosophila-
dc.subject.keywordAuthorGAL4/UAS-
dc.subject.keywordAuthorBehavior-
dc.subject.keywordAuthorNeurobiology-
dc.subject.keywordAuthorTechniques-
dc.subject.keywordPlusANTENNAL LOBE-
dc.subject.keywordPlusSYNAPTIC-TRANSMISSION-
dc.subject.keywordPlusNERVOUS-SYSTEM-
dc.subject.keywordPlusFLUORESCENT PROTEINS-
dc.subject.keywordPlusTARGETED EXPRESSION-
dc.subject.keywordPlusGENETIC APPROACH-
dc.subject.keywordPlusNEURAL PATHWAYS-
dc.subject.keywordPlusSENSORY NEURONS-
dc.subject.keywordPlusMUSHROOM BODIES-
dc.subject.keywordPlusFLY BRAIN-
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