DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yuk J.-M. | ko |
dc.contributor.author | Shin D.-M. | ko |
dc.contributor.author | Lee H.-M. | ko |
dc.contributor.author | Yang C.-S. | ko |
dc.contributor.author | Jin H.S. | ko |
dc.contributor.author | Kim K.-K. | ko |
dc.contributor.author | Lee Z.-W. | ko |
dc.contributor.author | Lee S.-H. | ko |
dc.contributor.author | Kim J.-M. | ko |
dc.contributor.author | Jo E.-K. | ko |
dc.date.accessioned | 2013-03-09T19:13:02Z | - |
dc.date.available | 2013-03-09T19:13:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | CELL HOST & MICROBE, v.6, no.3, pp.231 - 243 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97241 | - |
dc.description.abstract | Autophagy and vitamin D3-mediated innate immunity have been shown to confer protection against infection with intracellular Mycobacterium tuberculosis. Here, we show that these two antimycobacterial defenses are physiologically linked via a regulatory function of human cathelicidin (hCAP-18/LL-37), a member of the cathelicidin family of antimicrobial proteins. We show that 1,25-dihydroxyvitamin D (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5. 1,25D3 also induced the colocalization of mycobacterial phagosomes with autophagosomes in human macrophages in a cathelicidin-dependent manner. Furthermore, the antimycobacterial activity in human macrophages mediated by physiological levels of 1,25D3 required autophagy and cathelicidin. These results indicate that human cathelicidin, a protein that has direct antimicrobial activity, also serves as a mediator of vitamin D3-induced autophagy. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | INNATE IMMUNE-RESPONSES | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | HOST-DEFENSE | - |
dc.subject | C/EBP-BETA | - |
dc.subject | MACROPHAGES | - |
dc.subject | CELLS | - |
dc.subject | INHIBITION | - |
dc.title | Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin | - |
dc.type | Article | - |
dc.identifier.wosid | 000270290700007 | - |
dc.identifier.scopusid | 2-s2.0-69949184887 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 231 | - |
dc.citation.endingpage | 243 | - |
dc.citation.publicationname | CELL HOST & MICROBE | - |
dc.identifier.doi | 10.1016/j.chom.2009.08.004 | - |
dc.contributor.nonIdAuthor | Yuk J.-M. | - |
dc.contributor.nonIdAuthor | Shin D.-M. | - |
dc.contributor.nonIdAuthor | Lee H.-M. | - |
dc.contributor.nonIdAuthor | Yang C.-S. | - |
dc.contributor.nonIdAuthor | Jin H.S. | - |
dc.contributor.nonIdAuthor | Kim K.-K. | - |
dc.contributor.nonIdAuthor | Lee Z.-W. | - |
dc.contributor.nonIdAuthor | Kim J.-M. | - |
dc.contributor.nonIdAuthor | Jo E.-K. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | CELLBIO | - |
dc.subject.keywordAuthor | CELLIMMUNO | - |
dc.subject.keywordAuthor | MICROBIO | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | C/EBP-BETA | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
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