Integrated nanobiosensor technology for biomedical application

Abstract

Advances in nanotechnology have led to the development of nanoscale biosensors that have exquisite sensitivity and versatility. The biomedical application of nanobiosensors is wide; moreover, the future impact of nanobiosensors systems for point-of-care diagnostics will be unmatched. The ultimate goal of nanobiosensors is to detect any biochemical and biophysical signal associated with a specific disease at the level of a single molecule or cell. This technology will revolutionize conventional medical practices by enabling early diagnosis of chronic debilitating diseases, ultrasensitive detection of pathogens, and long-term monitoring of patients using biocompatible integrated medical instrumentation. In the present commentary, current state-of-the art principles of nanobiosensor systems and integration into lab-on-a-chip devices are discussed along with future perspectives.