DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hyosook | ko |
dc.contributor.author | Choi, Myunghwan | ko |
dc.contributor.author | Choi, Kyungsun | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2013-03-09T18:49:19Z | - |
dc.date.available | 2013-03-09T18:49:19Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.citation | MICROVASCULAR RESEARCH, v.82, no.2, pp.141 - 146 | - |
dc.identifier.issn | 0026-2862 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97191 | - |
dc.description.abstract | Because of high spatial resolution and superior tissue penetration, a femtosecond laser of the near-infrared spectrum has great potential to improve the efficacy of conventional photodynamic therapy; however, the lack of suitable photosensitizers has so far limited its bedside applications. Recently, our group reported that a brief irradiation by femtosecond lasers in the absence of exogenous probes can modulate various cellular behaviors in vitro and in vivo. Here, we demonstrate that targeted irradiation by a femtosecond laser disrupted tumor-associated blood vessels, and the inhibition of vascular endothelial growth factor signaling augmented the efficacy of laser-induced angiolysis. Further, we show that reactive oxygen species (ROS) are generated in response to laser irradiation, and reducing the intracellular levels of ROS rendered endothelial cells resistant to laser-induced cytotoxicity. Collectively, these results indicate that a femtosecond laser can be used as a vascular-disrupting therapeutic modality for cancer treatment, especially when used in combination with conventional anti-angiogenic therapies. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | MULTIPHOTON MICROSCOPY | - |
dc.subject | ANTIANGIOGENIC THERAPY | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | DRUG-RESISTANCE | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | NADPH OXIDASE | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | MECHANISMS | - |
dc.subject | CELLS | - |
dc.subject | VEGF | - |
dc.title | Blockade of vascular endothelial growth factor sensitizes tumor-associated vasculatures to angiolytic therapy with a high-frequency ultrashort pulsed laser | - |
dc.type | Article | - |
dc.identifier.wosid | 000293820200006 | - |
dc.identifier.scopusid | 2-s2.0-79960922711 | - |
dc.type.rims | ART | - |
dc.citation.volume | 82 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 141 | - |
dc.citation.endingpage | 146 | - |
dc.citation.publicationname | MICROVASCULAR RESEARCH | - |
dc.identifier.doi | 10.1016/j.mvr.2011.04.010 | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Choi, Hyosook | - |
dc.contributor.nonIdAuthor | Choi, Myunghwan | - |
dc.contributor.nonIdAuthor | Choi, Kyungsun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MULTIPHOTON MICROSCOPY | - |
dc.subject.keywordPlus | ANTIANGIOGENIC THERAPY | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | MULTIPHOTON MICROSCOPY | - |
dc.subject.keywordPlus | ANTIANGIOGENIC THERAPY | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | VEGF | - |
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